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3
제 2 항에 있어서,상기 키랄성 포스핀 리간드는 (R)-(+)-2,2'-Bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl((R)-3,5-xylyl-BINAP), (S)-(-)-2,2'-Bis(di-p-tolyphosphino)-1,1'-binaphthyl((S)-Tol-BINAP)), (+)- 1,2-Bis((2R,5R)-2,5-di-i-propylphospholano)benzene((R,R)-i-Pr-DUPHOS)), (-)-2,3-o-isopropylidene-2,3-dihydroxy-1,4-bis(denylphosphino)butane((-)-DIOP, (R,R)-DIOP), (2S,3S)-(-)-Bis(diphenylphosphino)butane((S,S)-CHIRAPHOS), (+)-2,3-o-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane((+)-DIOP, (S,S)-DIOP), (1S,2S)-(+)-bis[(2-methoxyphenyl)phenylphosphino]ethane ((S,S)-DIPAMP), (R)-1-[(1S)-2-(Diphenylphosphino)ferrocenyl]ethyl di-tert- butyl phosphine, (R)-1-[(1S)-2-(Diphenylphosphino)ferrocenyl]ethyl dicyclohexyl phosphine((R)-(S)-josiphos), (S)-1-[(1R)-2- (Diphenylphosphino)ferrocenyl]ethyldicyclohexyl-phosphine((S)-(R)-josiphos), R-(+)-6,6'-Bis(diphenylphosphino)-1,1'-biphenyl-2,2'-diylbis(acetate)((R)-Methyl Soniphos), S-(-)-6,6'-Bis(diphenylphosphino)-1,1'-biphenyl-2,2'- diylbis(acetate)((S)-Methyl Soniphos), R-(+)-6,6'-Bis(diphenylphosphino)- 1,1'-biphenyl-2,2'-diylbis(cyclohexylcarboxylate)((R)-cyclohexyl Soniphos), R-(+)-2,2'-Bis(N-diphenylphosphinoamino)- 5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl(CTH-(R)-BINAM), S-(-)-2,2'- Bis(N-diphenylphosphinoamino)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl(CTH-(S)-BINAM)로 이루어진 군에서 선택되는 것을 특징으로 하는 화학식 1의 1-아자스피로 화합물의 제조방법
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