요약, Int. CL, CPC, 출원번호/일자, 출원인, 등록번호/일자, 공개번호/일자, 공고번호/일자, 국제출원번호/일자, 국제공개번호/일자, 우선권정보, 법적상태, 심사진행상태, 심판사항, 구분, 원출원번호/일자, 관련 출원번호, 기술이전 희망, 심사청구여부/일자, 심사청구항수의 정보를 제공하는 이전대상기술 뷰 페이지 상세정보 > 서지정보 표입니다.
| 요약 |
A pharmaceutical composition for preventing or treating a neurodegenerative disease comprises a compound inhibiting a P25/CDK5(cycline-dependent kinase 5) complex as an active ingredient. Also disclosed is a method for screening a compound capable of preventing or treating a neurodegenerative disease, which comprises the steps of a) reacting a candidate compound with a P25/CDK5 complex and beta-site APP(amyloid precursor protein)-cleaving enzyme 1 (BACE1) or treating a mammalian cell expressing P25 with the candidate compound, and measuring BACE1 phosphorylation; and b) comparing the measured BACE1 phosphorylation with that of a control group employing no candidate compound, and identifying a compound reducing BACE1 phosphorylation compared to the control group. The compound inhibiting the P25/CDK5 complex may be useful for preventing or treating a neurodegenerative disease including Alzheimer's disease because it inhibits BACE1 phosphorylation and reduces the secretion of β-amyloid and the hyperphosphorylation of Tau.
|
| Int. CL |
A61K 31/381 (2006.01.01) A61K 31/635 (2014.01.01) A61P 25/28 (2006.01.01)
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| CPC |
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| 출원번호/일자 |
1020077017681
(2005.01.12)
|
| 출원인 |
인제대학교 산학협력단
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| 등록번호/일자 |
10-0931928-0000
(2009.12.07)
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| 공개번호/일자 |
10-2007-0094947
(2007.09.27)
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| 공고번호/일자 |
|
| 국제출원번호/일자 |
|
| 국제공개번호/일자 |
|
| 우선권정보 |
|
| 법적상태 |
소멸 |
| 심사진행상태 |
|
| 심판사항 |
|
| 구분 |
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| 원출원번호/일자 |
|
| 관련 출원번호 |
|
| 심사청구여부/일자 |
|
| 심사청구항수 |
0 |
