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하기 화학식 1로 표시되는 이미다졸-1-일 피리미딘 유도체, 또는 이의 약학적으로 허용가능한 염:[화학식 1]상기 화학식 1에서, Q1은 -CH2-이고;Q2는 -CO- 또는 -CONH-이며; R1은 클로로페닐(chlorophenyl), 디클로로페닐(dichlorophenyl), 플루오로페닐(fluorophenyl), 디메틸페닐(dimethylphenyl), 퀴놀린(quinolinyl), 피리디닐(pyridinyl), 피라진일(pyrazinyl), 1H-벤조트리아졸-5-일(1H-benzotriazol-5-yl), 비페닐-2-일(biphenyl-2-yl), 비페닐-4-일(biphenyl-4-yl), 트리플루오로메틸페닐(trifluoromethylphenyl), 비스(4-클로로페닐)메틸(bis(4-chlorophenyl)methyl), 2-클로로-5-(4-클로로벤질)페닐(2-chloro-5-(4-chlorobenzyl)phenyl), 비페닐-4-일-메틸(biphenyl-4-yl-methyl), 1-아세틸피페리딘-4-일(1-acetylpiperidin-4-yl), 5-(4-메톡시페닐)퓨란-2-일(5-(4-methoxyphenyl)furan-2-yl), 2-[(2-시아노페닐)설파닐]페닐 (2-[(2-cyanophenyl)sulfanyl]phenyl), 6-하이드록시-2,5,7,8-테트라메틸-3,4-디하이드로-2H-크로멘-2-일(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl), 비스(4-클로로페닐)메틸(bis(4-chlorophenyl)methyl), 4-(몰폴린-4-일)-3-트리플루오로메틸)페닐(4-(morpholin-4-yl)-3-(trifluoromethyl)phenyl), 3-(몰폴린-4-일)-4-트리플루오로메틸)페닐(3-(morpholin-4-yl)-4-(trifluoromethyl)phenyl), 3-(몰폴린-4-일)-5-트리플루오로메틸)페닐(3-(morpholin-4-yl)-5-(trifluoromethyl)phenyl), 1H-인돌-3-일-메틸(1H-indol-3-yl-methyl), 디하이드로-1H-인돌-2-일(dihydro-1H-indol-2-yl), 3-클로로-3-(트리플루오로메틸)페닐(3-chloro-4-(trifluoromethyl)phenyl), 3-(4-메틸피페라진-1-일)-5-(트리플루오로메틸)페닐(3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl), 4-[(4-에틸피페라진-1-일)메틸]-3-(트리플루오로메틸)페닐(4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl), 또는 3-(4-메틸피페라진-1-일-5-(트리플루오로메틸)페닐(3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl)이다
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제1항에 있어서, 상기 화학식 1은 하기 화합물들로 이루어진 군에서 선택되는 이미다졸-1-일 피리미딘 유도체, 또는 이의 약학적으로 허용가능한 염:(S)-N-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)-3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamide(S)-N-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)-3,5-dimethylbenzamide(S)-N-(4-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)pyrazine-2-carboxamide(S)-2-(2-fluorophenyl)-N-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)acetamide(S)-N-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide(S)-4-chloro-N-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)benzamide(S)-N-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)quinoline-2-carboxamide(S)-N-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)-1H-indole-3-carboxamide(S)-N-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)isonicotinamide(S)-N-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)-1H-benzo[d][1,2,3]triazole-5-carboxamide(S)-2-([1,1'-biphenyl]-4-yl)-N-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)acetamide(S)-N-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)-[1,1'-biphenyl]-4-carboxamide(S)-N-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)-[1,1'-biphenyl]-2-carboxamide(S)-1-acetyl-N-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)piperidine-4-carboxamide(S)-2-((2-cyanophenyl)thio)-N-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)benzamide(R)-6-hydroxy-N-(3-((1-(2-(((S)-2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)-2,5,7,8-tetramethylchromane-2-carboxamide(S)-2-chloro-5-(4-chlorobenzyl)-N-(3-((1-(2-((2-hydroxypropyl)amino)-pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)benzamide(S)-2,2-bis(4-chlorophenyl)-N-(3-((1-(2-(2-hydroxypropylamino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)acetamide(S)-N-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)-3-morpholino-2-(trifluoromethyl)benzamide(S)-4-chloro-N-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)-3-(trifluoromethyl)benzamide(S)-N-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)-3-morpholino-5-(trifluoromethyl)benzamide(S)-1-(3-chlorophenyl)-3-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)urea(S)-1-(3,4-dichlorophenyl)-3-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)urea(S)-1-(3-chloro-4-(trifluoromethyl)phenyl)-3-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)urea(S)-1-(3-((4-ethylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)-3-(3-((1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)phenyl)urea
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