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CRP, S100P, TFF1, FGA, FGL1, APCS, TM4SF4, FGB, C8G, FGG, GAL3ST1, TMEM27, ALB, CXCL6, HABP2, DEFB1, CHST4, ACMSD, UGT2B17, VTN, CITED4, SPP1, FXYD2, KRT23, PDGFD, ASGR2, CLDN10, SCTR, VTCN1, AKAP7, PDZK1, APCDD1, SNURF, SNAP25, GSTT1, ANXA13, APOB, SNRPN, ABCB1, FRAS1, SLC4A4, CPB2, CLDN1, RASD1, ZNF467, LDOC1, COLEC11, MYH11, PTHLH, COMP, HOMER2, CNTNAP2, A1CF, GATS, SEMA6A, HLA-DRB5, BAAT, SERPINE2, AGTR1, LAMC3, SYNGR1, GAMT, DCDC2, FGFR3, MGP, CFH, CAV2, EVC, SPARCL1, AQP1, TMPRSS6, SPOCK1, CA9, AEBP1, C1QTNF5, STOM, RGS4, ELFN2, PALM, C6, C5, PRICKLE1, FAM149A, DAB2, ADAMTSL2, ACTA2, RELN, STMN2, EFHD1, PTGFR, HSPA6, GUCY1A3, KRT80, PDE5A, TMEM156, CDH6, RERG, FBLN2, SDC1, CTSC, LINGO1, PLAT, FLNC, CHST9, SRPX2, FAXDC2, REEP6, DMKN, ID3, SYT13, UBASH3B, FNDC1, ADORA2B, HKDC1, PPARGC1A, UGT2B11, LRRC75B, VASN, ADCK2, APOE, LRRN2, PAMR1, RBPMS2, LAMP2, PPP1R14C, VWF, PPP1R14A, HIST2H2AC, SEC14L4, COL1A2, C1R, HTRA1, SLC27A3, SLC25A23, MFAP4, UGT2B4, THBS2, LBP, FST, ISLR, OGDHL, CERS2, COL1A1, CDKN1A, TAGLN, PPAP2A, ODC1, PCOLCE, FBLN1, CHST13, HIST2H2AA3, FARP1, ATP1A1, HYAL1, HEYL, ANO6, HNF1B, ACTG2, TMEM119, CXCL8, PTRF, HOGA1, CX3CL1, GLRB, ITIH2, LUM, PCCA, INHBE, DKK3, SGCA, DCN, PDGFRB, SORBS2, SERPING1, CFI, GC, PLLP, COL15A1, MAOA, TPST1, PTH1R, TPST2, INHBB, HIST1H2AC, OLFML2A, ASGR1, SPATA20, STRADB, NDUFA4L2, SFRP4, COMTD1, ADCY9, RAP1GAP, CCDC74A, GRM8, SEL1L3, ANGPTL2, ITIH5, PHYHIPL, TBX2, HIST1H1C, HSPA1B, CKB, HSD3B7, FAHD1, DNM1, MYH10, COL5A1, ERICH5, HSD17B2, SPTSSA, SLC2A3, PMEPA1, KLHL3, PTP4A3, CKMT2, CNNM1, ADAMTS1, DNAJB1, HIST1H2BG, TLDC2, NRBP2, SLC29A4, ID2, SMOC2, KYNU, IGFBP5, SRPX, FAM171A1, GGT1, TTC39C, OPN3, RAB36, CLEC11A, F5, PTPRM, EPDR1, TPCN2, KCNF1, PAQR5, MKKS, MFGE8, MMD, COX7A1, ARF5, DNALI1, GUCA2A, TNFSF10, TMEM37, UGT2B7, GLDC, COL4A2, F10, ENG, CYP2C8, ERP27, GEM, TRPV6, CSPG4, FGF3, EEPD1, DENND6B, COL10A1, BAIAP2L1, COL8A1, MEIS2, HSPB6, CRYAB, GMNN, NOL3, SERPINA5, SERPINA7, STBD1, GALK1, H2AFJ, TGFB3, SLC17A4, TFAP2A, TNC, CHCHD10, SULT2B1, SLC9A3R1, TRIB3, EPHB6, C8B, SPARC, CAP2, GLIPR2, SLIT2, TSPAN6, CMTM3, TMEM205, TGM2, ZIC2, CAPS, RNASE4, CLCNKA, CLDN9, CAV1, HLA-DRB4, MYOF, NUDT9, TAX1BP3, NPTX1, IGFBP1, DUSP1, SMA4, DHRS7, TRIM15, TIMP2, TNFSF12, FMO1, MASP1, CXCL2, CYP4A11, EFEMP2, ID1, METRN, TESC, C7, CD248, SLC24A3, HYI, CYP3A5, THY1, CCDC3, MMP10, PVRL3, RPS23, PHLDB1, PPP1R13L, TRAK2, C1QL1, WDR91, SORBS1, CD58, DUSP23, TMEM61, NR5A2, ATP6V0E2, CPE, PECR, CDH11, PRSS23, TM4SF18, PPP1R15A, ABCC3, WNK2, TMEM204, GYPC, COL4A1, GHR, HPN, PLAC9, TIMM22, NRTN, LEPROTL1, TUBG2, HIST1H2BD, UGT2A3, GJB1, ERN1, HSD17B11, LAMA2, MYL9, SLC4A3, DNAJC22, BTG1, GGT6, GAS6, RASAL2, HOMER3, SCARB2, LGALS1, CYB5D1, MSRB3, CLEC3B, KRT10, MAPK10, CUEDC1, SMPDL3A, COL4A5, PMM1, PBX3, SRGN, CD59, MYL6B, ANXA5, PCSK1N, COL6A2, ENAH, TEAD2, HIST1H2BK, VIM, MAPK12, ZNF219, ELOVL2, TACC1, MAMDC2, MMP23A, SEMA3E, HLA-DRB1, KLHL9, FSTL3, CXCR4, ORM2, SGSM2, COL18A1, SPON1, CERCAM, TNFRSF12A, ARL4C, LYPD1, NDUFS7, NPY5R, KLHL5, TTC25, ALAD, PGBD5, TRIP6, FAM89A, RAB31, WDR72, TLE1, TMEM99, DTNA, CYGB, NUAK2, UBE2L3, SOX18, NFIB, SMOX, OLR1, TSPAN4, COL3A1, NT5C3B, WDR54, RBP1, MAMLD1, CLN3, SOX13, PROS1, BNIP3, NFIX, SH3PXD2A, COMT, BMP2, CGN, RALB, MAOB, MYLK, ITGB5, TP53INP1, SLC23A1, SIRPA, GNLY, FCGR2A, TCEA2, GALNT18, C1QL4, ST3GAL5, GJA4, FAM129A, BPHL, BMP6, KLHL22, COL14A1, RARA, LURAP1L, EVA1B, VEZF1, IGFBP6, LARP6, TP53TG1, HIST2H2BE, GLTSCR2, CNN1, FRMD4A, SCN1B, SOCS2, DSEL, GPC1, JAG2, FIS1, CPQ, KISS1, ANG, MAPK15, CLDN18, TFF2, LCN2, CDCA7, CTSE, TFF3, KRT17, PLA2G10, ACSL5, LYZ, SLC44A4, ANXA10, KLK6, TSPAN8, CYP2S1, TSPAN13, GSTA1, VSIG2, GSTA2, AOC1, FAM83E, SERPINB5, KCTD14, SH3BGRL2, CXCL5, PSAT1, ERN2, GJB2, PGC, OAS3, PLAC8, FAM3D, GPRC5A, CEACAM5, OAS1, FOXQ1, CELSR3, GABRP, TRIM31, MOCOS, MT1G, MUC13, IL1RN, TMC5, AGR2, NCOA7, TMEM45B, PRSS3, SFTA2, MAB21L2, CYP4F12, PTPRR, UBE2C, KLK11, VILL, CDC42EP5, EFHD2, MYB, AKR7L, BIK, ZDHHC11, REG1A, CAPN9, FUT2, AGR3, BPIFB1, ERAP2, CEACAM1, PTMA, CDC20, UAP1, MLPH, SULT1C2, MID1, NET1, MX1, MT1M, KRT6B, CCNB2, LY6E, RARRES1, SLC5A8, OAS2, TMEM144, ASPM, PRAME, MYBPC1, YRDC, IRAK2, FABP6, GCNT3, SLC2A2, PLA2G16, APOD, SNX29P2, CLIC6, TKT, TTK, UBE2T, ALDH3A1, LGALS4, GNL3, CKS2, MUC1, UCHL1, TDRD1, KCNJ13, GALNT3, SLC7A1, IFI6, IFI44, TSEN2, FAM63A, LMOD3, ADD3, TMPRSS3, RPLP1, PGD, EVPL, GSDMB, NCAPG, CEP55, UBP1, TXNRD1, TRIP13, IFI44L, MECOM, PLEKHS1, LEMD1, TOP2A, TCN1, FBP1, IBTK, KRAS, EAF1, PSG1, USP49, ATL3, CAPN13, TMPRSS2, STEAP1, HES6, GAD1, AGMAT, ITPR3, SAP30, RSRP1, PTTG1, SUMO2, TNFRSF6B, CD164, CPS1, GALE, CCDC58, RNASEH2B, SPDYE1, CKMT1B, HACD4, SLC22A23, EFNB1, LINC01296, EMILIN2, CDCA5, GALNT4, SLC43A3, RPL14, SKP2, CDK11A, CERS6, TAMM41, LSM3, DNAJC15, TXLNGY, ZNF451, MFSD11, MOGAT1, SLAIN1, KCNK1, HDAC2, VHL, LGALS2, HJURP, SFN, PKIA, SCD, YTHDF2, VWA5A, SPN, CLEC2D, HMGB1P1, RPS4Y1, SOX8, SCML1, PRC1, FXYD3, NQO1, NUP210, NOP58, GALNT12, HRASLS2, RCC1, ASAP2, ME1, ZNF93, CYB5R2, PARP9, TMEM243, HIPK2, ALPP, CLIC3, RNF213, PIP4K2B, DUOXA2, GDI2, GSTA5, CENPF, SPSB2, ZNF223, SLMAP, UBE2J1, CCL2, ARF4, EDN1, CCNK, IYD, DUOX2, SAPCD2, GPR160, PROSER1, SACM1L, HOXB7, RAP1B, OSBPL7, SLC27A2, COLEC12, HSPA14, MITD1, ATPIF1, FXYD4, USP48, OASL, ASCL2, STK26, PARPBP, TIPARP, PAPOLA, MIS18BP1, CDKN3, ICA1L, NUP107, DENND2D, CSTF2, PIGR, CENPW, HAUS2, HSD17B7, POGLUT1, GTPBP4, LTV1, MAT1A, TM9SF3, LONRF3, MGST1, HMGB2, TCP1, CDH17, NCCRP1, GSTP1, AQP9, NR4A2, PRSS21, HMGCS1, IDI1, POMP, TPK1, SCGB3A1, BRIX1, NMD3, NANS, RPP40, RAB6A, POLQ, INSM1, PUS1, UBE2E1, TACC3, PTPRH, ANLN, G6PD, ADPRHL1, RFX5, MAGEA6, BCLAF1, C4BPB, TOMM70A, DKC1, XPC, RNGTT, NNMT, OR4K15, TRNT1, SLC38A11, SYTL2, DNAJC12, EVI5 및 LRP8 유전자 또는 상기 유전자로 엔코딩된 단백질을 포함하는 간내담도암 예후 예측용 바이오마커 조성물
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CRP, S100P, TFF1, FGA, FGL1, APCS, TM4SF4, FGB, C8G, FGG, GAL3ST1, TMEM27, ALB, CXCL6, HABP2, DEFB1, CHST4, ACMSD, UGT2B17, VTN, CITED4, SPP1, FXYD2, KRT23, PDGFD, ASGR2, CLDN10, SCTR, VTCN1, AKAP7, PDZK1, APCDD1, SNURF, SNAP25, GSTT1, ANXA13, APOB, SNRPN, ABCB1, FRAS1, SLC4A4, CPB2, CLDN1, RASD1, ZNF467, LDOC1, COLEC11, MYH11, PTHLH, COMP, HOMER2, CNTNAP2, A1CF, GATS, SEMA6A, HLA-DRB5, BAAT, SERPINE2, AGTR1, LAMC3, SYNGR1, GAMT, DCDC2, FGFR3, MGP, CFH, CAV2, EVC, SPARCL1, AQP1, TMPRSS6, SPOCK1, CA9, AEBP1, C1QTNF5, STOM, RGS4, ELFN2, PALM, C6, C5, PRICKLE1, FAM149A, DAB2, ADAMTSL2, ACTA2, RELN, STMN2, EFHD1, PTGFR, HSPA6, GUCY1A3, KRT80, PDE5A, TMEM156, CDH6, RERG, FBLN2, SDC1, CTSC, LINGO1, PLAT, FLNC, CHST9, SRPX2, FAXDC2, REEP6, DMKN, ID3, SYT13, UBASH3B, FNDC1, ADORA2B, HKDC1, PPARGC1A, UGT2B11, LRRC75B, VASN, ADCK2, APOE, LRRN2, PAMR1, RBPMS2, LAMP2, PPP1R14C, VWF, PPP1R14A, HIST2H2AC, SEC14L4, COL1A2, C1R, HTRA1, SLC27A3, SLC25A23, MFAP4, UGT2B4, THBS2, LBP, FST, ISLR, OGDHL, CERS2, COL1A1, CDKN1A, TAGLN, PPAP2A, ODC1, PCOLCE, FBLN1, CHST13, HIST2H2AA3, FARP1, ATP1A1, HYAL1, HEYL, ANO6, HNF1B, ACTG2, TMEM119, CXCL8, PTRF, HOGA1, CX3CL1, GLRB, ITIH2, LUM, PCCA, INHBE, DKK3, SGCA, DCN, PDGFRB, SORBS2, SERPING1, CFI, GC, PLLP, COL15A1, MAOA, TPST1, PTH1R, TPST2, INHBB, HIST1H2AC, OLFML2A, ASGR1, SPATA20, STRADB, NDUFA4L2, SFRP4, COMTD1, ADCY9, RAP1GAP, CCDC74A, GRM8, SEL1L3, ANGPTL2, ITIH5, PHYHIPL, TBX2, HIST1H1C, HSPA1B, CKB, HSD3B7, FAHD1, DNM1, MYH10, COL5A1, ERICH5, HSD17B2, SPTSSA, SLC2A3, PMEPA1, KLHL3, PTP4A3, CKMT2, CNNM1, ADAMTS1, DNAJB1, HIST1H2BG, TLDC2, NRBP2, SLC29A4, ID2, SMOC2, KYNU, IGFBP5, SRPX, FAM171A1, GGT1, TTC39C, OPN3, RAB36, CLEC11A, F5, PTPRM, EPDR1, TPCN2, KCNF1, PAQR5, MKKS, MFGE8, MMD, COX7A1, ARF5, DNALI1, GUCA2A, TNFSF10, TMEM37, UGT2B7, GLDC, COL4A2, F10, ENG, CYP2C8, ERP27, GEM, TRPV6, CSPG4, FGF3, EEPD1, DENND6B, COL10A1, BAIAP2L1, COL8A1, MEIS2, HSPB6, CRYAB, GMNN, NOL3, SERPINA5, SERPINA7, STBD1, GALK1, H2AFJ, TGFB3, SLC17A4, TFAP2A, TNC, CHCHD10, SULT2B1, SLC9A3R1, TRIB3, EPHB6, C8B, SPARC, CAP2, GLIPR2, SLIT2, TSPAN6, CMTM3, TMEM205, TGM2, ZIC2, CAPS, RNASE4, CLCNKA, CLDN9, CAV1, HLA-DRB4, MYOF, NUDT9, TAX1BP3, NPTX1, IGFBP1, DUSP1, SMA4, DHRS7, TRIM15, TIMP2, TNFSF12, FMO1, MASP1, CXCL2, CYP4A11, EFEMP2, ID1, METRN, TESC, C7, CD248, SLC24A3, HYI, CYP3A5, THY1, CCDC3, MMP10, PVRL3, RPS23, PHLDB1, PPP1R13L, TRAK2, C1QL1, WDR91, SORBS1, CD58, DUSP23, TMEM61, NR5A2, ATP6V0E2, CPE, PECR, CDH11, PRSS23, TM4SF18, PPP1R15A, ABCC3, WNK2, TMEM204, GYPC, COL4A1, GHR, HPN, PLAC9, TIMM22, NRTN, LEPROTL1, TUBG2, HIST1H2BD, UGT2A3, GJB1, ERN1, HSD17B11, LAMA2, MYL9, SLC4A3, DNAJC22, BTG1, GGT6, GAS6, RASAL2, HOMER3, SCARB2, LGALS1, CYB5D1, MSRB3, CLEC3B, KRT10, MAPK10, CUEDC1, SMPDL3A, COL4A5, PMM1, PBX3, SRGN, CD59, MYL6B, ANXA5, PCSK1N, COL6A2, ENAH, TEAD2, HIST1H2BK, VIM, MAPK12, ZNF219, ELOVL2, TACC1, MAMDC2, MMP23A, SEMA3E, HLA-DRB1, KLHL9, FSTL3, CXCR4, ORM2, SGSM2, COL18A1, SPON1, CERCAM, TNFRSF12A, ARL4C, LYPD1, NDUFS7, NPY5R, KLHL5, TTC25, ALAD, PGBD5, TRIP6, FAM89A, RAB31, WDR72, TLE1, TMEM99, DTNA, CYGB, NUAK2, UBE2L3, SOX18, NFIB, SMOX, OLR1, TSPAN4, COL3A1, NT5C3B, WDR54, RBP1, MAMLD1, CLN3, SOX13, PROS1, BNIP3, NFIX, SH3PXD2A, COMT, BMP2, CGN, RALB, MAOB, MYLK, ITGB5, TP53INP1, SLC23A1, SIRPA, GNLY, FCGR2A, TCEA2, GALNT18, C1QL4, ST3GAL5, GJA4, FAM129A, BPHL, BMP6, KLHL22, COL14A1, RARA, LURAP1L, EVA1B, VEZF1, IGFBP6, LARP6, TP53TG1, HIST2H2BE, GLTSCR2, CNN1, FRMD4A, SCN1B, SOCS2, DSEL, GPC1, JAG2, FIS1, CPQ, KISS1, ANG, MAPK15, CLDN18, TFF2, LCN2, CDCA7, CTSE, TFF3, KRT17, PLA2G10, ACSL5, LYZ, SLC44A4, ANXA10, KLK6, TSPAN8, CYP2S1, TSPAN13, GSTA1, VSIG2, GSTA2, AOC1, FAM83E, SERPINB5, KCTD14, SH3BGRL2, CXCL5, PSAT1, ERN2, GJB2, PGC, OAS3, PLAC8, FAM3D, GPRC5A, CEACAM5, OAS1, FOXQ1, CELSR3, GABRP, TRIM31, MOCOS, MT1G, MUC13, IL1RN, TMC5, AGR2, NCOA7, TMEM45B, PRSS3, SFTA2, MAB21L2, CYP4F12, PTPRR, UBE2C, KLK11, VILL, CDC42EP5, EFHD2, MYB, AKR7L, BIK, ZDHHC11, REG1A, CAPN9, FUT2, AGR3, BPIFB1, ERAP2, CEACAM1, PTMA, CDC20, UAP1, MLPH, SULT1C2, MID1, NET1, MX1, MT1M, KRT6B, CCNB2, LY6E, RARRES1, SLC5A8, OAS2, TMEM144, ASPM, PRAME, MYBPC1, YRDC, IRAK2, FABP6, GCNT3, SLC2A2, PLA2G16, APOD, SNX29P2, CLIC6, TKT, TTK, UBE2T, ALDH3A1, LGALS4, GNL3, CKS2, MUC1, UCHL1, TDRD1, KCNJ13, GALNT3, SLC7A1, IFI6, IFI44, TSEN2, FAM63A, LMOD3, ADD3, TMPRSS3, RPLP1, PGD, EVPL, GSDMB, NCAPG, CEP55, UBP1, TXNRD1, TRIP13, IFI44L, MECOM, PLEKHS1, LEMD1, TOP2A, TCN1, FBP1, IBTK, KRAS, EAF1, PSG1, USP49, ATL3, CAPN13, TMPRSS2, STEAP1, HES6, GAD1, AGMAT, ITPR3, SAP30, RSRP1, PTTG1, SUMO2, TNFRSF6B, CD164, CPS1, GALE, CCDC58, RNASEH2B, SPDYE1, CKMT1B, HACD4, SLC22A23, EFNB1, LINC01296, EMILIN2, CDCA5, GALNT4, SLC43A3, RPL14, SKP2, CDK11A, CERS6, TAMM41, LSM3, DNAJC15, TXLNGY, ZNF451, MFSD11, MOGAT1, SLAIN1, KCNK1, HDAC2, VHL, LGALS2, HJURP, SFN, PKIA, SCD, YTHDF2, VWA5A, SPN, CLEC2D, HMGB1P1, RPS4Y1, SOX8, SCML1, PRC1, FXYD3, NQO1, NUP210, NOP58, GALNT12, HRASLS2, RCC1, ASAP2, ME1, ZNF93, CYB5R2, PARP9, TMEM243, HIPK2, ALPP, CLIC3, RNF213, PIP4K2B, DUOXA2, GDI2, GSTA5, CENPF, SPSB2, ZNF223, SLMAP, UBE2J1, CCL2, ARF4, EDN1, CCNK, IYD, DUOX2, SAPCD2, GPR160, PROSER1, SACM1L, HOXB7, RAP1B, OSBPL7, SLC27A2, COLEC12, HSPA14, MITD1, ATPIF1, FXYD4, USP48, OASL, ASCL2, STK26, PARPBP, TIPARP, PAPOLA, MIS18BP1, CDKN3, ICA1L, NUP107, DENND2D, CSTF2, PIGR, CENPW, HAUS2, HSD17B7, POGLUT1, GTPBP4, LTV1, MAT1A, TM9SF3, LONRF3, MGST1, HMGB2, TCP1, CDH17, NCCRP1, GSTP1, AQP9, NR4A2, PRSS21, HMGCS1, IDI1, POMP, TPK1, SCGB3A1, BRIX1, NMD3, NANS, RPP40, RAB6A, POLQ, INSM1, PUS1, UBE2E1, TACC3, PTPRH, ANLN, G6PD, ADPRHL1, RFX5, MAGEA6, BCLAF1, C4BPB, TOMM70A, DKC1, XPC, RNGTT, NNMT, OR4K15, TRNT1, SLC38A11, SYTL2, DNAJC12, EVI5 및 LRP8 유전자에 특이적으로 결합하는 프라이머 또는 프로브, 상기 유전자로 엔코딩된 단백질에 특이적으로 결합하는 항체 또는 상기 단백질에 특이적인 결합 도메인을 갖는 펩타이드를 포함하는 간내담도암 예후 예측용 키트
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간내담도암 환자 시료로부터 CRP, S100P, TFF1, FGA, FGL1, APCS, TM4SF4, FGB, C8G, FGG, GAL3ST1, TMEM27, ALB, CXCL6, HABP2, DEFB1, CHST4, ACMSD, UGT2B17, VTN, CITED4, SPP1, FXYD2, KRT23, PDGFD, ASGR2, CLDN10, SCTR, VTCN1, AKAP7, PDZK1, APCDD1, SNURF, SNAP25, GSTT1, ANXA13, APOB, SNRPN, ABCB1, FRAS1, SLC4A4, CPB2, CLDN1, RASD1, ZNF467, LDOC1, COLEC11, MYH11, PTHLH, COMP, HOMER2, CNTNAP2, A1CF, GATS, SEMA6A, HLA-DRB5, BAAT, SERPINE2, AGTR1, LAMC3, SYNGR1, GAMT, DCDC2, FGFR3, MGP, CFH, CAV2, EVC, SPARCL1, AQP1, TMPRSS6, SPOCK1, CA9, AEBP1, C1QTNF5, STOM, RGS4, ELFN2, PALM, C6, C5, PRICKLE1, FAM149A, DAB2, ADAMTSL2, ACTA2, RELN, STMN2, EFHD1, PTGFR, HSPA6, GUCY1A3, KRT80, PDE5A, TMEM156, CDH6, RERG, FBLN2, SDC1, CTSC, LINGO1, PLAT, FLNC, CHST9, SRPX2, FAXDC2, REEP6, DMKN, ID3, SYT13, UBASH3B, FNDC1, ADORA2B, HKDC1, PPARGC1A, UGT2B11, LRRC75B, VASN, ADCK2, APOE, LRRN2, PAMR1, RBPMS2, LAMP2, PPP1R14C, VWF, PPP1R14A, HIST2H2AC, SEC14L4, COL1A2, C1R, HTRA1, SLC27A3, SLC25A23, MFAP4, UGT2B4, THBS2, LBP, FST, ISLR, OGDHL, CERS2, COL1A1, CDKN1A, TAGLN, PPAP2A, ODC1, PCOLCE, FBLN1, CHST13, HIST2H2AA3, FARP1, ATP1A1, HYAL1, HEYL, ANO6, HNF1B, ACTG2, TMEM119, CXCL8, PTRF, HOGA1, CX3CL1, GLRB, ITIH2, LUM, PCCA, INHBE, DKK3, SGCA, DCN, PDGFRB, SORBS2, SERPING1, CFI, GC, PLLP, COL15A1, MAOA, TPST1, PTH1R, TPST2, INHBB, HIST1H2AC, OLFML2A, ASGR1, SPATA20, STRADB, NDUFA4L2, SFRP4, COMTD1, ADCY9, RAP1GAP, CCDC74A, GRM8, SEL1L3, ANGPTL2, ITIH5, PHYHIPL, TBX2, HIST1H1C, HSPA1B, CKB, HSD3B7, FAHD1, DNM1, MYH10, COL5A1, ERICH5, HSD17B2, SPTSSA, SLC2A3, PMEPA1, KLHL3, PTP4A3, CKMT2, CNNM1, ADAMTS1, DNAJB1, HIST1H2BG, TLDC2, NRBP2, SLC29A4, ID2, SMOC2, KYNU, IGFBP5, SRPX, FAM171A1, GGT1, TTC39C, OPN3, RAB36, CLEC11A, F5, PTPRM, EPDR1, TPCN2, KCNF1, PAQR5, MKKS, MFGE8, MMD, COX7A1, ARF5, DNALI1, GUCA2A, TNFSF10, TMEM37, UGT2B7, GLDC, COL4A2, F10, ENG, CYP2C8, ERP27, GEM, TRPV6, CSPG4, FGF3, EEPD1, DENND6B, COL10A1, BAIAP2L1, COL8A1, MEIS2, HSPB6, CRYAB, GMNN, NOL3, SERPINA5, SERPINA7, STBD1, GALK1, H2AFJ, TGFB3, SLC17A4, TFAP2A, TNC, CHCHD10, SULT2B1, SLC9A3R1, TRIB3, EPHB6, C8B, SPARC, CAP2, GLIPR2, SLIT2, TSPAN6, CMTM3, TMEM205, TGM2, ZIC2, CAPS, RNASE4, CLCNKA, CLDN9, CAV1, HLA-DRB4, MYOF, NUDT9, TAX1BP3, NPTX1, IGFBP1, DUSP1, SMA4, DHRS7, TRIM15, TIMP2, TNFSF12, FMO1, MASP1, CXCL2, CYP4A11, EFEMP2, ID1, METRN, TESC, C7, CD248, SLC24A3, HYI, CYP3A5, THY1, CCDC3, MMP10, PVRL3, RPS23, PHLDB1, PPP1R13L, TRAK2, C1QL1, WDR91, SORBS1, CD58, DUSP23, TMEM61, NR5A2, ATP6V0E2, CPE, PECR, CDH11, PRSS23, TM4SF18, PPP1R15A, ABCC3, WNK2, TMEM204, GYPC, COL4A1, GHR, HPN, PLAC9, TIMM22, NRTN, LEPROTL1, TUBG2, HIST1H2BD, UGT2A3, GJB1, ERN1, HSD17B11, LAMA2, MYL9, SLC4A3, DNAJC22, BTG1, GGT6, GAS6, RASAL2, HOMER3, SCARB2, LGALS1, CYB5D1, MSRB3, CLEC3B, KRT10, MAPK10, CUEDC1, SMPDL3A, COL4A5, PMM1, PBX3, SRGN, CD59, MYL6B, ANXA5, PCSK1N, COL6A2, ENAH, TEAD2, HIST1H2BK, VIM, MAPK12, ZNF219, ELOVL2, TACC1, MAMDC2, MMP23A, SEMA3E, HLA-DRB1, KLHL9, FSTL3, CXCR4, ORM2, SGSM2, COL18A1, SPON1, CERCAM, TNFRSF12A, ARL4C, LYPD1, NDUFS7, NPY5R, KLHL5, TTC25, ALAD, PGBD5, TRIP6, FAM89A, RAB31, WDR72, TLE1, TMEM99, DTNA, CYGB, NUAK2, UBE2L3, SOX18, NFIB, SMOX, OLR1, TSPAN4, COL3A1, NT5C3B, WDR54, RBP1, MAMLD1, CLN3, SOX13, PROS1, BNIP3, NFIX, SH3PXD2A, COMT, BMP2, CGN, RALB, MAOB, MYLK, ITGB5, TP53INP1, SLC23A1, SIRPA, GNLY, FCGR2A, TCEA2, GALNT18, C1QL4, ST3GAL5, GJA4, FAM129A, BPHL, BMP6, KLHL22, COL14A1, RARA, LURAP1L, EVA1B, VEZF1, IGFBP6, LARP6, TP53TG1, HIST2H2BE, GLTSCR2, CNN1, FRMD4A, SCN1B, SOCS2, DSEL, GPC1, JAG2, FIS1, CPQ, KISS1, ANG, MAPK15, CLDN18, TFF2, LCN2, CDCA7, CTSE, TFF3, KRT17, PLA2G10, ACSL5, LYZ, SLC44A4, ANXA10, KLK6, TSPAN8, CYP2S1, TSPAN13, GSTA1, VSIG2, GSTA2, AOC1, FAM83E, SERPINB5, KCTD14, SH3BGRL2, CXCL5, PSAT1, ERN2, GJB2, PGC, OAS3, PLAC8, FAM3D, GPRC5A, CEACAM5, OAS1, FOXQ1, CELSR3, GABRP, TRIM31, MOCOS, MT1G, MUC13, IL1RN, TMC5, AGR2, NCOA7, TMEM45B, PRSS3, SFTA2, MAB21L2, CYP4F12, PTPRR, UBE2C, KLK11, VILL, CDC42EP5, EFHD2, MYB, AKR7L, BIK, ZDHHC11, REG1A, CAPN9, FUT2, AGR3, BPIFB1, ERAP2, CEACAM1, PTMA, CDC20, UAP1, MLPH, SULT1C2, MID1, NET1, MX1, MT1M, KRT6B, CCNB2, LY6E, RARRES1, SLC5A8, OAS2, TMEM144, ASPM, PRAME, MYBPC1, YRDC, IRAK2, FABP6, GCNT3, SLC2A2, PLA2G16, APOD, SNX29P2, CLIC6, TKT, TTK, UBE2T, ALDH3A1, LGALS4, GNL3, CKS2, MUC1, UCHL1, TDRD1, KCNJ13, GALNT3, SLC7A1, IFI6, IFI44, TSEN2, FAM63A, LMOD3, ADD3, TMPRSS3, RPLP1, PGD, EVPL, GSDMB, NCAPG, CEP55, UBP1, TXNRD1, TRIP13, IFI44L, MECOM, PLEKHS1, LEMD1, TOP2A, TCN1, FBP1, IBTK, KRAS, EAF1, PSG1, USP49, ATL3, CAPN13, TMPRSS2, STEAP1, HES6, GAD1, AGMAT, ITPR3, SAP30, RSRP1, PTTG1, SUMO2, TNFRSF6B, CD164, CPS1, GALE, CCDC58, RNASEH2B, SPDYE1, CKMT1B, HACD4, SLC22A23, EFNB1, LINC01296, EMILIN2, CDCA5, GALNT4, SLC43A3, RPL14, SKP2, CDK11A, CERS6, TAMM41, LSM3, DNAJC15, TXLNGY, ZNF451, MFSD11, MOGAT1, SLAIN1, KCNK1, HDAC2, VHL, LGALS2, HJURP, SFN, PKIA, SCD, YTHDF2, VWA5A, SPN, CLEC2D, HMGB1P1, RPS4Y1, SOX8, SCML1, PRC1, FXYD3, NQO1, NUP210, NOP58, GALNT12, HRASLS2, RCC1, ASAP2, ME1, ZNF93, CYB5R2, PARP9, TMEM243, HIPK2, ALPP, CLIC3, RNF213, PIP4K2B, DUOXA2, GDI2, GSTA5, CENPF, SPSB2, ZNF223, SLMAP, UBE2J1, CCL2, ARF4, EDN1, CCNK, IYD, DUOX2, SAPCD2, GPR160, PROSER1, SACM1L, HOXB7, RAP1B, OSBPL7, SLC27A2, COLEC12, HSPA14, MITD1, ATPIF1, FXYD4, USP48, OASL, ASCL2, STK26, PARPBP, TIPARP, PAPOLA, MIS18BP1, CDKN3, ICA1L, NUP107, DENND2D, CSTF2, PIGR, CENPW, HAUS2, HSD17B7, POGLUT1, GTPBP4, LTV1, MAT1A, TM9SF3, LONRF3, MGST1, HMGB2, TCP1, CDH17, NCCRP1, GSTP1, AQP9, NR4A2, PRSS21, HMGCS1, IDI1, POMP, TPK1, SCGB3A1, BRIX1, NMD3, NANS, RPP40, RAB6A, POLQ, INSM1, PUS1, UBE2E1, TACC3, PTPRH, ANLN, G6PD, ADPRHL1, RFX5, MAGEA6, BCLAF1, C4BPB, TOMM70A, DKC1, XPC, RNGTT, NNMT, OR4K15, TRNT1, SLC38A11, SYTL2, DNAJC12, EVI5 및 LRP8 유전자의 mRNA 발현 수준 또는 상기 유전자로 엔코딩된 단백질의 발현 수준을 측정하는 단계; 및상기 유전자의 mRNA 발현 수준 또는 상기 유전자로 엔코딩된 단백질의 발현 수준을 대조군 시료와 비교하는 단계를 포함하는 간내담도암 예후 예측에 유용한 정보를 제공하는 방법
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제 3항에 있어서,상기 mRNA 발현 수준을 측정하는 방법은 RT-PCR, 경쟁적 RT-PCR(Competitive RT-PCR), 실시간 RT-PCR (Real-time RT-PCR), RNase 보호 분석법 (RPA; RNase protection assay), 노던 블랏팅 (Northern blotting) 및 DNA 칩으로 이루어진 군에서 선택된 어느 하나를 이용하여 측정하는 것을 특징으로 하는 간내담도암 예후 예측에 유용한 정보를 제공하는 방법
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제 3항에 있어서,상기 단백질 발현 수준을 측정하는 방법은 웨스턴 블랏, ELISA(enzyme linked immunosorbent asay), 방사선면역분석(Radioimmunoassay; RIA), 방사면역확산법(radioimmunodiffusion), 오우크테로니(Ouchterlony) 면역 확산법, 로케이트(rocket) 면역전기영동, 조직면역염색, 면역침전 분석법(Immunoprecipitation assay), 보체고정분석법(Complement Fixation Assay), FACS 및 단백질 칩으로 이루어진 군에서 선택된 어느 하나를 이용하여 측정하는 것을 특징으로 하는 간내담도암 예후 예측에 유용한 정보를 제공하는 방법
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