| 1 |
1
하기 화학식 1을 갖는 신규 방사성 화합물 또는 그의 허용가능한 염:(화학식 1)(상기 식에서 X1은 18F, 76Br, 123I, 124I, 및 131I로 구성되는 군으로부터 선택되는 방사성 동위 할로겐원소 또는 NOTA(1,4,7-triazacyclononane-N,N',N"-triacetic acid), DOTA(tetraazacyclododecane-1,4,7,10-tetraacetic acid), DTPA(diethylenetriaminepentaacetic acid), 및 TETA(1,4,8,11-tetraazacyclotetradecane-N',N",N"'-tetraacetic acid)로 구성되는 군으로부터 선택되는 킬레이터 및 68Ga, Al18F, 62Cu 및, 64Cu로 구성되는 군으로부터 선택되는 방사성 금속 또는 방사성 금속염의 착물일 수 있고, X2 및 X3는 각각 독립적으로 C 또는 N으로 이들 중 적어도 하나는 N이고 상기 n은 1 내지 5의 정수이다)
|
| 2 |
2
제1항에 있어서, N-(2-(dimethylamino)ethyl)-6-[18F]fluoronicotimamide, N-(2-(dimethylamino)ethyl)-6-[123I]iodonicotimamide, N-(2-(dimethylamino)ethyl)-6-[124I]iodonicotinamide, N-(2-(dimethylamino)ethyl)-6-[131I]iodonicotinamide, N-(2-(dimethylamino)ethyl)-6-[76Br]bromonicotinamide, N-(3-(dimethylamino)propyl)-6-[18F]fluoronicotinamide, N-(3-(dimethylamino)propyl)-6-[123I]iodonicotinamide, N-(3-(dimethylamino)propyl)-6-[124I]iodonicotinamide, N-(3-(dimethylamino)propyl)-6-[131I]iodonicotinamide, N-(3-(dimethylamino)propyl)-6-[76Br]bromonicotinamide, N-(4-(dimethylamino)butyl)-6-[18F]fluoronicotinamide, N-(4-(dimethylamino)butyl)-6-[123I]iodonicotinamide, N-(4-(dimethylamino)butyl)-6-[124I]iodonicotinamide, N-(4-(dimethylamino)butyl)-6-[131I]iodonicotinamide, N-(4-(dimethylamino)butyl)-6-[76Br]bromonicotinamide, N-(5-(dimethylamino)pentyl)-6-[18F]fluoronicotinamide, N-(5-(dimethylamino)pentyl)-6-[123I]iodonicotinamide, N-(5-(dimethylamino)pentyl)-6-[124I]iodonicotinamide, N-(5-(dimethylamino)pentyl)-6-[131I]iodonicotinamide, N-(5-(dimethylamino)pentyl)-6-[76Br]bromonicotinamide, N-(6-(dimethylamino)hexyl)-6-[18F]fluoronicotinamide, N-(6-(dimethylamino)hexyl)-6-[123I]iodonicotinamide, N-(6-(dimethylamino)hexyl)-6-[124I]iodonicotinamide, N-(6-(dimethylamino)hexyl)-6-[131I]iodonicotinamide, N-(6-(dimethylamino)hexyl)-6-[76Br]bromonicotinamide, N-(2-(dimethylamino)ethyl)-5-[18F]fluoropicolinamide, N-(2-(dimethylamino)ethyl)-5-[123I]iodopicolinamide, N-(2-(dimethylamino)ethyl)-5-[124I]iodopicolinamide, N-(2-(dimethylamino)ethyl)-5-[131I]iodopicolinamide, N-(2-(dimethylamino)ethyl)-5-[76Br]bromopicolinamide, N-(3-(dimethylamino)propyl)-5-[18F]fluoropicolinamide, N-(3-(dimethylamino)propyl)-5-[123I]iodopicolinamide, N-(3-(dimethylamino)propyl)-5-[124I]iodopicolinamide, N-(3-(dimethylamino)propyl)-5-[131I]iodopicolinamide, N-(3-(dimethylamino)propyl)-5-[76Br]bromopicolinamide, N-(4-(dimethylamino)butyl)-5-[18F]fluoropicolinamide, N-(4-(dimethylamino)butyl)-5-[123I]iodopicolinamide, N-(4-(dimethylamino)butyl)-5-[124I]iodopicolinamide, N-(4-(dimethylamino)butyl)-5-[131I]iodopicolinamide, N-(4-(dimethylamino)butyl)-5-[76Br]bromopicolinamide, N-(5-(dimethylamino)pentyl)-5-[18F]fluoropicolinamide, N-(5-(dimethylamino)pentyl)-5-[123I]iodopicolinamide, N-(5-(dimethylamino)pentyl)-5-[124I]iodopicolinamide, N-(5-(dimethylamino)pentyl)-5-[131I]iodopicolinamide, N-(5-(dimethylamino)pentyl)-5-[76Br]bromopicolinamide, N-(6-(dimethylamino)hexyl)-5-[18F]fluoropicolinamide, N-(6-(dimethylamino)hexyl)-5-[123I]iodopicolinamide, N-(6-(dimethylamino)hexyl)-5-[124I]iodopicolinamide, N-(6-(dimethylamino)hexyl)-5-[131I]iodopicolinamide, N-(6-(dimethylamino)hexyl)-5-[76Br]bromopicolinamide, N-(2-(dimethylamino)ethyl)-6-[18F]fluoropyridazine-3-carboxamide, N-(2-(dimethylamino)ethyl)-6-[123I]iodopyridazine-3-carboxamide, N-(2-(dimethylamino)ethyl)-6-[124I]iodopyridazine-3-carboxamide, N-(2-(dimethylamino)ethyl)-6-[131I]iodopyridazine-3-carboxamide, N-(2-(dimethylamino)ethyl)-6-[76Br]bromopyridazine-3-carboxamide, N-(3-(dimethylamino)propyl)-6-[18F]fluoropyridazine-3-carboxamide, N-(3-(dimethylamino)propyl)-6-[123I]iodopyridazine-3-carboxamide, N-(3-(dimethylamino)propyl)-6-[124I]iodopyridazine-3-carboxamide, N-(3-(dimethylamino)propyl)-6-[131I]iodopyridazine-3-carboxamide, N-(3-(dimethylamino)propyl)-6-[76Br]bromopyridazine-3-carboxamide, N-(4-(dimethylamino)butyl)-6-[18F]fluoropyridazine-3-carboxamide, N-(4-(dimethylamino)butyl)-6-[123I]iodopyridazine-3-carboxamide, N-(4-(dimethylamino)butyl)-6-[124I]iodopyridazine-3-carboxamide, N-(4-(dimethylamino)butyl)-6-[131I]iodopyridazine-3-carboxamide, N-(4-(dimethylamino)butyl)-6-[76Br]bromopyridazine-3-carboxamide, N-(5-(dimethylamino)pentyl)-6-[18F]fluoropyridazine-3-carboxamide, N-(5-(dimethylamino)pentyl)-6-[123I]iodopyridazine-3-carboxamide, N-(5-(dimethylamino)pentyl)-6-[124I]iodopyridazine-3-carboxamide, N-(5-(dimethylamino)pentyl)-6-[131I]iodopyridazine-3-carboxamide, N-(5-(dimethylamino)pentyl)-6-[76Br]bromopyridazine-3-carboxamide, N-(6-(dimethylamino)hexyl)-6-[18F]fluoropyridazine-3-carboxamide, N-(6-(dimethylamino)hexyl)-6-[123I]iodopyridazine-3-carboxamide, N-(6-(dimethylamino)hexyl)-6-[124I]iodopyridazine-3-carboxamide, N-(6-(dimethylamino)hexyl)-6-[131I]iodopyridazine-3-carboxamide, N-(6-(dimethylamino)hexyl)-6-[76Br]bromopyridazine-3-carboxamide인, 화합물 또는 그의 허용가능한 염
|
