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4
제3항에 있어서,상기 단백질은 CaMKII, PLN(phospholamban), STIM1(stromal interaction molecule 1), Complex I/III/IV, DRP1(dynamin-1-like protein), VDAC(voltage-dependent anion channel), FXR(farnesyl X receptor), BMAL1(brain and muscle ARNT-like 1), CLOCK(circadian locomotor output cycles kaput), CRTC2(CREB regulated transcription coactivator 2), FOXO1(forkhead box protein O1), PGC-1α(peroxisome proliferator-activated receptor gamma coactivator 1-alpha), IRS1(insulin receptor substrate 1), AKT(protein kinase B), ChREBP(carbohydrate-responsive element-binding protein), NFATc1(nuclear factor of activated T-cells, cytoplsmic 1), NF-κB(nuclear factor kappa-light-chain-enhancer of activated B cells), TAK1(mitogen-activated protein kinase kinase kinase 7), C/EBP-β(CCAAT/enhancer-binding protein beta ), PPARγ(peroxisome proliferator-activated receptor gamma), IR-β(insulin receptor beta), Sp1(Sp1 transcription factor), RUNX2(Runt-related transcription factor 2), MEF2D(monocyte-specific enhancer factor 2D), CREB(cAMP response element binding protein), Milton, α-synuclein, tau, KCNQ3(potassium voltage-gated channel subfamily Q member 3), GluA2(glutamate transport ATP-bidning protein), periaxin(PRX), c-Myc, FOXM1(forkhead box protein M1), G6PD(glucose-6-phosphate dehyrogenase), PFK1m(phophofructokinase-1), TET1(Tet methylcytosine dioxygenase), OCT4(octamer-binding transcription factor 4), SOX2(sex determining region Y-Box 2), BCKD(Branched chain ketoacid dehydrogenase), GYS2(glycogen synthase 2), KCNB1(potassium voltage-gated channel subfamily B), KPB1(Phosphorylase b kinase regulatory subunit), MYBB(Myb-like protein B), MYPC3(Myosin Binding Protein C), KIF2C(Kinesin Family Member 2C), RBL-2(RB Transcriptional Corepressor Like 2), DHX30(DExH-Box Helicase 30), NCOA2(Nuclear Receptor Coactivator 2), NCOA3(Nuclear Receptor Coactivator 3), NCOA6(Nuclear Receptor Coactivator 6), NRIP1(Nuclear Receptor Interacting Protein 1), MED1(Mediator Complex Subunit 1), NR0B2(Nuclear Receptor Subfamily 0 Group B Member 2), BRD8(Bromodomain Containing 8), NRIP1(Nuclear Receptor Interacting Protein 1), PRGR(progesterone receptor), LCOR(Ligand-dependent corepressor), WIPI1(WD repeat domain phosphoinositide-interacting protein 1), RRP1B(Ribosomal RNA Processing 1B), CDKN2AIP(CDKN2A Interacting Protein), VIM(Vimentins), TPR(Translocated Promoter Region), SPTBN1(Spectrin Beta, Non-Erythrocytic 1), RANBP2(RAN Binding Protein 2), HIST1H3A(Histone Cluster 1 H3 Family Member A), KRT8(keratin-8), NUMA1(Nuclear Mitotic Apparatus Protein 1), PHB(PHB), EMSY(BRCA2 Interacting Transcriptional Repressor), CRTC2(CREB Regulated Transcription Coactivator 2), NUP214(Nucleoporin 214), CAMK4(Calcium/Calmodulin Dependent Protein Kinase IV), BPTF(Bromodomain PHD Finger Transcription Factor), HCFC1(VP16-accessory protein HCF), KRT18(Keratin 18), POM121(POM121 Transmembrane Nucleoporin), RBM14(RNA Binding Motif Protein 14), ATXN2L(Ataxin 2 Like), SNCA(alpha-synuclein), IKBKB(Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta), Esr1( Estrogen Receptor 1), Sptbn1(Spectrin Beta, Non-Erythrocytic 1), Ablim1(Actin Binding LIM Protein 1), Skt(KIAA1217), Nos3(Nitric Oxide Synthase 3), Lbr(Lamin B Receptor), Mapt(microtubule-associated protein tau), Prkcb(Protein Kinase C Beta), Prkcd(Protein Kinase C Delta), Prkce(Protein Kinase C Epsilon), Prkcg(Protein Kinase C Gamma), GAPDH(glyceraldehyde-3-phosphate dehydrogenase), 또는 WIPI1(WD repeat domain phosphoinositide-interacting protein 1)인, 방법
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5
제3항에 있어서,상기 펩타이드는 BCKD_45_27(ERSKTVTSFYNQS, 서열번호 65), GYS2_1_13(MLRGRSLSVTSLG, 서열번호 66), KCNB1_489_501(KWTKRTLSETSSS, 서열번호 67), KPB1_1011_1023(QVEFRRLSISAES, 서열번호 68), MYBB_513_525(DNTPHTPTPFKNA, 서열번호 69), MYPC3_266_280(LSAFRRTSLAGGG, 서열번호 70), KIF2C_105_118_S106G(EGLRSRSTRMSTVS, 서열번호 71), RBL-2_410_422(KENSPCVTPVSTA, 서열번호 72), RBL-2_655_667(GLGRSITSPTTLY, 서열번호 73), DHX30_241_262(QFPLPKNLLAKVIQIATSSSTA, 서열번호 74), NCOA2_866_888(SQSTFNNPRPGQLGRLLPNQNLP, 서열번호 75), NCOA3_MOUSE_1029_1051(HGSQNRPLLRNSLDDLLGPPSNA, 서열번호 76), NCOA6_1479_1501(LVSPAMREAPTSLSQLLDNSGAR, 서열번호 77), NRIP1_121_143_P124R(DSVRKGKQDSTLLASLLQSFSSR, 서열번호 78), MED1_591_614(HGEDFSKVSQNPILTSLLQITGNG, 서열번호 79), NR0B2_9_31_C9S/C11S(SPSQGAASRPAILYALLSSSLKA, 서열번호 80), BRD8_254_276(TVAASPAASGAPTLSRLLEAGPT, 서열번호 81), NRIP1_8_30(GSDVHQDSIVLTYLEGLLMHQAA, 서열번호 82), NRIP1_253_275_C263S(PATSPKPSVASSQLALLLSSEAH, 서열번호 83), PRGR_42_64_C64S(SDTLPEVSAIPISLDGLLFPRPS, 서열번호 84), LCOR_40_62(TTSPTAATTQNPVLSKLLMADQD, 서열번호 85) 또는 WIPI1_313_335_C318S(GQRNISTLSTIQKLPRLLVASSS, 서열번호 86)인, 방법
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