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전장 유전체 연관 분석 및 가족력 정보를 이용한 알레르기성 질환 예측 방법

  • 기술번호 : KST2022020783
  • 담당센터 : 서울동부기술혁신센터
  • 전화번호 : 02-2155-3662
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요약, Int. CL, CPC, 출원번호/일자, 출원인, 등록번호/일자, 공개번호/일자, 공고번호/일자, 국제출원번호/일자, 국제공개번호/일자, 우선권정보, 법적상태, 심사진행상태, 심판사항, 구분, 원출원번호/일자, 관련 출원번호, 기술이전 희망, 심사청구여부/일자, 심사청구항수의 정보를 제공하는 이전대상기술 뷰 페이지 상세정보 > 서지정보 표입니다.
요약 최근 소아 알레르기성 만성 질환의 유병율은 증가하는 추세이며, 이는 경제적 부담의 증가와 삶의 질 저하를 야기하고 있다. 특히 알레르기성 질환이 동시에 나타나는 경우 그 정도는 더 심하게 나타난다. 알레르기성 질환을 사전에 예측하는 것은 고위험군의 알레르기성 질환의 발병 속도를 늦추기 위한 주요한 방법이 될 수 있다. 본 발명은 한국인 환자의 전장 유전체 연관 분석(GWAS) 결과 및 가족력 자료를 이용하여 천식, 아토피성 피부염(AD) 및 천식-AD 동반 질환의 예측 모델에 관한 것이다. 환자와 비환자 대조군으로부터 단일염기 다형성(single nucleotide polymorphism, SNP)에 의한 유전율을 계산하였으며, LASSO와 ridge 회귀모형을 사용하여 만든 예측 모형의 성능을 비교하였다. 그 결과, 천식과 천식-AD 동반 질환 예측시 가족력 정보의 추가로 인해 예측 성능이 크게 향상되는 것을 확인하였다.
Int. CL G16B 40/20 (2019.01.01) G16B 20/20 (2019.01.01) G16B 30/10 (2019.01.01) C12Q 1/6883 (2018.01.01)
CPC G16B 40/20(2013.01) G16B 20/20(2013.01) G16B 30/10(2013.01) C12Q 1/6883(2013.01)
출원번호/일자 1020210056727 (2021.04.30)
출원인 서울대학교산학협력단, 연세대학교 산학협력단
등록번호/일자
공개번호/일자 10-2022-0149283 (2022.11.08) 문서열기
공고번호/일자
국제출원번호/일자
국제공개번호/일자
우선권정보
법적상태 공개
심사진행상태 수리
심판사항
구분 국내출원/신규
원출원번호/일자
관련 출원번호
심사청구여부/일자 N
심사청구항수 15

출원인

번호, 이름, 국적, 주소의 정보를 제공하는 이전대상기술 뷰 페이지 상세정보 > 인명정보 - 출원인 표입니다.
번호 이름 국적 주소
1 서울대학교산학협력단 대한민국 서울특별시 관악구
2 연세대학교 산학협력단 대한민국 서울특별시 서대문구

발명자

번호, 이름, 국적, 주소의 정보를 제공하는 이전대상기술 뷰 페이지 상세정보 > 인명정보 - 발명자 표입니다.
번호 이름 국적 주소
1 원성호 서울특별시 강남구
2 박재현 서울특별시 서초구
3 김경원 서울특별시 종로구
4 장혜린 경기도 광명시 광명역로 **,

대리인

번호, 이름, 국적, 주소의 정보를 제공하는 이전대상기술 뷰 페이지 상세정보 > 인명정보 - 대리인 표입니다.
번호 이름 국적 주소
1 장제환 대한민국 서울특별시 강남구 언주로 ***, **층 (역삼동, 윤익빌딩)(*T국제특허법률사무소)
2 이처영 대한민국 서울특별시 강남구 언주로 ***, **층 (역삼동, 윤익빌딩)(*T국제특허법률사무소)

최종권리자

번호, 이름, 국적, 주소의 정보를 제공하는 이전대상기술 뷰 페이지 상세정보 > 인명정보 - 최종권리자 표입니다.
번호 이름 국적 주소
최종권리자 정보가 없습니다
번호, 서류명, 접수/발송일자, 처리상태, 접수/발송일자의 정보를 제공하는 이전대상기술 뷰 페이지 상세정보 > 행정처리 표입니다.
번호 서류명 접수/발송일자 처리상태 접수/발송번호
1 [특허출원]특허출원서
[Patent Application] Patent Application		 2021.04.30 수리 (Accepted) 1-1-2021-0509156-70
2 특허고객번호 정보변경(경정)신고서·정정신고서
 2021.07.29 수리 (Accepted) 4-1-2021-5205564-29
3 특허고객번호 정보변경(경정)신고서·정정신고서
 2022.04.04 수리 (Accepted) 4-1-2022-5079741-71
4 특허고객번호 정보변경(경정)신고서·정정신고서
 2022.08.11 수리 (Accepted) 4-1-2022-5189083-38
5 특허고객번호 정보변경(경정)신고서·정정신고서
 2022.10.07 수리 (Accepted) 4-1-2022-5235636-01
6 특허고객번호 정보변경(경정)신고서·정정신고서
 2022.10.07 수리 (Accepted) 4-1-2022-5235822-97
번호, 청구항의 정보를 제공하는 이전대상기술 뷰 페이지 상세정보 > 청구항 표입니다.
번호 청구항
1 1
다음 단계를 포함하는 알레르기성 질환(allergic disease)의 진단 또는 예측을 위한 정보제공방법:(a) 분리된 생물학적 시료로부터 핵산을 추출하여 서열정보를 획득하고, 획득한 서열정보로부터 최고 선형 비편파적 예측 변수(best linear unbiased predictor, BLUP)의 절대값을 이용하여 단일염기 다형성(Single Nucleotide Polymorphism, SNP) 정보를 수집하는 단계;(b) 환자의 알레르기성 질환의 가족력 정보를 수집하는 단계; 및(c) 상기 수집한 단일염기 다형성 정보 및 가족력 정보를 벌점 회귀 방법(penalized regression method)으로 분석하여 알레르기성 질환 발병 확률을 계산하는 단계
2 2
제1항에 있어서, 상기 (a) 단계는 GCTA64 프로그램을 사용하여 계산한 최고 선형 비편파적 예측 변수의 절대값이 가장 큰 상위 100개 내지 10,000개의 단일염기 다형성을 선택하는 것을 특징으로 하는 방법
3 3
제2항에 있어서,상기 단일염기 다형성은 rs9999955; rs9992474; rs9992011; rs9989875; rs997200; rs9967427; rs9939521; rs9913225; rs9908504; rs9890911; rs989023; rs9817356; rs975563; rs9676717; rs9593109; rs9574681; rs956090; rs9534442; rs9529278; rs9527336; rs9508434; rs9499572; rs949280; rs9468829; rs944722; rs9426823; rs9400121; rs9397196; rs9379168; rs9368649; rs9368038; rs9358193; rs934819; rs9347511; rs931258; rs9303016; rs924992; rs914978; rs913056; rs906475; rs905278; rs888444; rs885962; rs877886; rs874697; rs871167; rs855586; rs854651; rs850254; rs842990; rs8114269; rs8100697; rs8075604; rs8056247; rs805512; rs8040937; rs803447; rs8022851; rs8014848; rs7996510; rs7994343; rs7987260; rs7980470; rs7979863; rs7976497; rs7972655; rs7972640; rs7950479; rs793779; rs7937695; rs792806; rs7909432; rs7908544; rs7905816; rs7904674; rs7893643; rs788040; rs7864653; rs7856856; rs7850923; rs7827405; rs7805578; rs7797977; rs7797565; rs7787128; rs7776974; rs7774359; rs7771293; rs776754; rs7737438; rs7732695; rs772305; rs7701633; rs7684116; rs766023; rs7660035; rs7639103; rs763448; rs7633394; rs7627455; rs7599151; rs7598162; rs758994; rs7589434; rs7582882; rs7563451; rs7552924; rs7552304; rs7541950; rs7541494; rs7528354; rs7516050; rs7513053; rs7512262; rs7506794; rs7420856; rs7419051; rs7411507; rs7403021; rs7359943; rs733905; rs731573; rs7313354; rs7312751; rs7309847; rs729129; rs7288250; rs727628; rs7240224; rs7226279; rs7224129; rs7214443; rs7213078; rs7211140; rs7187204; rs7186704; rs7183244; rs7165207; rs7148745; rs7142575; rs7134553; rs7130589; rs7126614; rs7114186; rs7095596; rs709397; rs7093309; rs7076021; rs7070233; rs706076; rs6979207; rs6973480; rs6963263; rs6947160; rs6943730; rs6908834; rs6880752; rs686262; rs6845844; rs6845317; rs6844408; rs6843038; rs6831421; rs6801905; rs6790154; rs6789471; rs6768580; rs6758936; rs6734462; rs6731061; rs6725395; rs6715109; rs6708202; rs6703335; rs6700410; rs6681092; rs6650254; rs6603867; rs6601105; rs6589722; rs6587905; rs6587673; rs6572807; rs6553317; rs6512171; rs6495246; rs6488271; rs6485247; rs6468864; rs6452775; rs6445961; rs6422002; rs638268; rs6127152; rs6089553; rs6061245; rs6016963; rs6013997; rs5750824; rs560978; rs538847; rs535780; rs524554; rs516125; rs5015847; rs4977977; rs4954603; rs4953640; rs495062; rs4942587; rs4939726; rs4928089; rs4926465; rs4918237; rs4896501; rs4895598; rs4883194; rs4880802; rs4867981; rs4867032; rs4859540; rs4852178; rs4850014; rs4843257; rs4833457; rs481145; rs4805038; rs479938; rs4798157; rs4797949; rs4785193; rs4772723; rs4758371; rs4758051; rs4752200; rs4751667; rs4746261; rs4745450; rs4744435; rs4741606; rs4730044; rs4729671; rs4727001; rs4711710; rs4711091; rs4692196; rs4689767; rs4673364; rs4671327; rs4669806; rs4668878; rs4664346; rs464526; rs4631821; rs4620259; rs4617129; rs4602829; rs4574937; rs4553816; rs4553283; rs4547102; rs4532345; rs4454154; rs445198; rs4446534; rs4396968; rs436806; rs4298454; rs4262792; rs4260136; rs425140; rs4247116; rs4245302; rs4239166; rs4235203; rs4234841; rs419958; rs4144116; rs4130296; rs4075705; rs407050; rs3990579; rs3923477; rs3915401; rs388516; rs3848599; rs383123; rs3825422; rs3823923; rs3823624; rs3821873; rs3812741; rs3810935; rs3775582; rs3775307; rs3773926; rs3771892; rs3745913; rs3744583; rs3742039; rs36693; rs349504; rs338415; rs329095; rs3117940; rs3109433; rs3096279; rs3092170; rs3088322; rs3015469; rs3013300; rs2998050; rs2995765; rs2980796; rs2961638; rs2919471; rs2913578; rs2898656; rs2887087; rs28859095; rs2884029; rs2876142; rs2855510; rs2853651; rs2838808; rs2833952; rs2830885; rs2824153; rs2820878; rs2769330; rs2760547; rs2728060; rs2718107; rs2717947; rs2716129; rs2715368; rs2706859; rs2695; rs2691583; rs2691437; rs2686527; rs2652024; rs2651980; rs2618148; rs2603430; rs2581566; rs252895; rs2503838; rs2484661; rs2477893; rs2453727; rs2412048; rs2406067; rs2399955; rs2298156; rs2298155; rs2296006; rs2283933; rs2268689; rs2251336; rs2249818; rs2246053; rs2242448; rs2242174; rs2240322; rs2236742; rs219221; rs2190073; rs2182833; rs2176298; rs2152310; rs2146971; rs2145445; rs2143934; rs2128434; rs2120233; rs2116378; rs2115619; rs2107449; rs2101938; rs2100700; rs2098836; rs2079278; rs2076339; rs2074027; rs2073514; rs2073242; rs2072855; rs2071042; rs2071018; rs205474; rs2042279; rs2041874; rs2039076; rs2038571; rs2031604; rs2025448; rs2023405; rs2017901; rs200760; rs1999874; rs1981905; rs1967380; rs1959919; rs1956369; rs1948147; rs1926226; rs1925189; rs1925164; rs1921561; rs1917851; rs1892356; rs1890112; rs1889170; rs1888363; rs1884062; rs1881584; rs1876304; rs1861239; rs1860261; rs1857994; rs1856309; rs1853155; rs1837253; rs1827656; rs1825225; rs1816713; rs1805126; rs178397; rs17834306; rs1781740; rs17759689; rs17676607; rs17644334; rs1764109; rs17551174; rs17443388; rs1741327; rs17391596; rs17164861; rs17154601; rs17119479; rs17115807; rs17114159; rs17103253; rs17094912; rs17094148; rs17078801; rs17064318; rs17063391; rs17063374; rs17056307; rs17051193; rs17039519; rs17033085; rs17026284; rs17011359; rs1699596; rs16961303; rs16959781; rs16939429; rs16933522; rs16927986; rs16853934; rs16851176; rs16827308; rs1680635; rs1629172; rs1628975; rs1607498; rs1577808; rs1577595; rs1575443; rs1570089; rs1566366; rs155368; rs1552243; rs1531807; rs1515656; rs150207; rs1493917; rs1490051; rs1489400; rs1485197; rs1484555; rs1475539; rs1442849; rs1421463; rs1413533; rs140005; rs1385337; rs1380643; rs1370182; rs1357616; rs1354156; rs1351656; rs1346028; rs1341021; rs13376101; rs1330742; rs13241587; rs1321368; rs13176223; rs130191; rs13011455; rs13000537; rs12977037; rs12938347; rs12901901; rs12892140; rs1282275; rs12822258; rs12790557; rs1278942; rs1275680; rs12709528; rs12708583; rs12692341; rs12683296; rs12671333; rs12647338; rs12641446; rs12637875; rs12589892; rs1257193; rs12564800; rs12555424; rs12554627; rs12548556; rs12544599; rs12543745; rs12538107; rs12511039; rs12497502; rs12495599; rs12488994; rs12444352; rs12440161; rs12402938; rs12379948; rs12372169; rs12365183; rs12326115; rs12278256; rs12223637; rs1219538; rs12186488; rs1217744; rs12135243; rs12133803; rs12094886; rs12092254; rs12089394; rs1207273; rs1205726; rs12048287; rs12042467; rs12041851; rs11897585; rs11891861; rs11844663; rs11788529; rs11786952; rs11773181; rs11724270; rs11710380; rs11700063; rs11677281; rs11673295; rs11666645; rs11655336; rs11653011; rs11648981; rs11638680; rs1160575; rs11580074; rs1153451; rs11264352; rs11260542; rs11258651; rs11256351; rs11218070; rs11184168; rs11155607; rs11155050; rs11149863; rs11141878; rs11140989; rs11140976; rs11132829; rs11123636; rs11098326; rs11075440; rs11048567; rs10984425; rs10966921; rs10941665; rs10939282; rs10938478; rs10937641; rs10928541; rs10926538; rs10912054; rs10900864; rs10894219; rs10887273; rs10886222; rs10884017; rs10878824; rs10866177; rs10859780; rs10859547; rs10850508; rs10845265; rs10842275; rs10840701; rs10798674; rs10791393; rs10790969; rs10788679; rs10777331; rs10772943; rs1076710; rs10758513; rs10756644; rs10756061; rs10753764; rs1074390; rs10737772; rs10734897; rs1061280; rs10518707; rs10517903; rs10512197; rs10509543; rs10500751; rs10492797; rs10486860; rs10485734; rs1048380; rs10468473; rs10444397; rs10431384; rs10407076; rs10274919; rs1026504; rs10261983; rs10255815; rs1025246; rs1024961; rs10239038; rs10232481; rs10206626; rs10179086; rs10148233; rs10146857; rs10142804; rs10138135; rs10130832; rs10129333; rs10128729; rs10124883; rs10078324; rs10075707; rs10056747; rs10026312; rs10008418; rs10004274; kgp874165; kgp6156665; kgp3323585; kgp11307318; kgp11032999; exm-rs9912468; exm-rs9303277; exm-rs830998; exm-rs8067378; exm-rs8055236; exm-rs7217319; exm-rs703842; exm-rs6445975; exm-rs4142041; exm-rs385893; exm-rs3094694; exm-rs1999805; exm-rs12917698; exm-rs1233478; exm-rs10777332; exm770959; exm68990; exm634421; exm573467; exm56992; exm529509; exm508989; exm508988; exm378731; exm344344; exm29843; exm2270205; exm2270172; exm2269560; exm2269242; exm2268964; exm2268830; exm2268323; exm2268119; exm2266840; exm2266655; exm2265762; exm2265292; exm2260947; exm2259513; exm2258282; exm2257389; exm2254258; exm2253580; exm2252025; exm2251246; exm217591; exm198816; exm1545953; exm1542; exm1475551; exm1415695; exm1180102; exm1161911; exm1113037; exm1104615; exm1054965; 및 exm104672로 구성된 군에서 선택되고,상기 알레르기성 질환은 천식(asthma)인 것을 특징으로 하는 정보제공방법
4 4
제3항에 있어서,rs7856856; rs17033085; rs1890112; rs7512262; rs12554627; rs854651; rs9400121; rs792806; rs5750824; rs2298156; rs7904674; rs4942587; rs2820878; rs17551174; exm2254258; rs1489400; rs4928089; rs4668878; rs3088322; rs9992474; rs7070233; rs2072855; rs805512; rs383123; rs495062; rs17094912; rs2031604; rs1577595; rs1205726; rs9913225; rs7627455; rs3823624; rs6963263; rs3915401; rs12822258; rs10842275; rs7183244; rs17644334; rs2913578; rs4235203; rs4751667; rs16939429; rs975563; rs733905; rs4711710; rs1680635; rs9426823; rs1351656; rs4797949; rs10431384; rs6845844; rs4239166; rs6016963; rs4260136; rs130191; rs913056; rs1484555; rs10938478; rs3823923; rs1837253; rs17078801; rs7684116; kgp6156665; rs2998050; rs6422002; rs10232481; rs12790557; rs9368038; rs4396968; rs12365183; rs3771892; rs3810935; rs11666645; exm56992; rs4772723; rs10146857; rs11218070; rs10937641; rs479938; rs2017901; rs1282275; rs11258651; rs12041851; rs4867981; rs12511039; rs4234841; rs6880752; rs10939282; rs2283933; rs12555424; rs7598162; rs3775307; rs12223637; rs17114159; rs7660035; exm1180102; rs11897585; rs7130589; rs12402938; exm1113037; exm-rs1233478; rs7909432; rs12538107; rs2717947; rs7076021; rs219221; rs17115807; rs6089553; rs4926465; rs766023; rs1926226; rs6488271; rs8114269; rs7864653; rs3775582; rs9508434; exm2265292; rs13011455; rs17094148; rs793779; rs155368; rs6908834; rs2071018; rs1917851; rs10486860; rs6831421; rs3015469; rs11184168; exm2269242; exm-rs385893; rs1024961; rs11048567; rs4669806; rs9593109; rs10772943; rs4689767; rs4532345; rs1628975; rs140005; rs7288250; rs10468473; rs1925164; rs2980796; rs7552924; rs855586; rs2098836; rs2107449; rs1485197; rs10004274; rs7980470; rs17759689; rs1861239; rs6452775; rs4130296; rs7148745; rs12892140; exm508988; rs7994343; rs9529278; rs10758513; rs8014848; rs2176298; rs2715368; rs1570089; rs524554; rs7114186; rs11786952; rs4075705; rs16959781; rs7599151; rs12544599; rs6013997; rs2603430; rs1956369; rs1278942; rs10239038; rs7187204; rs10798674; rs2887087; rs12133803; rs2120233; rs6789471; rs905278; rs3092170; rs1699596; rs7905816; rs1493917; rs2038571; rs12977037; exm1475551; rs10509543; rs11773181; rs10148233; rs1385337; rs6844408; rs538847; exm2266840; rs706076; rs2190073; rs7737438; rs6843038; rs1413533; rs2042279; rs1552243; rs6801905; rs997200; rs4692196; rs12379948; rs3848599; rs2074027; rs10255815; rs349504; rs6943730; rs1566366; rs2236742; rs2100700; rs3773926; rs803447; rs12089394; rs13376101; rs709397; rs6790154; rs6127152; rs10912054; rs12692341; rs10129333; exm2268964; rs4746261; rs2116378; rs4553816; rs4245302; rs7165207; exm198816; rs9527336; rs1061280; rs2182833; rs10124883; rs10274919; rs7226279; rs17164861; rs10966921; rs638268; rs178397; rs2073514; rs9908504; exm1054965; rs1856309; rs1341021; rs4711091; rs13000537; rs2691437; rs727628; rs445198; rs1575443; rs2686527; rs7528354; rs1380643; rs9358193; exm1161911; rs16933522; exm2253580; kgp3323585; rs7186704; rs2145445; rs1207273; rs6572807; rs4977977; rs10517903; rs10941665; rs10928541; rs4833457; rs877886; rs2251336; rs2399955; rs4744435; rs10138135; rs12589892; rs4664346; rs7732695; rs28859095; rs7639103; exm344344; rs7313354; rs4758051; rs9499572; exm378731; rs2716129; rs2249818; rs1853155; rs10753764; rs11638680; rs388516; rs10926538; rs9992011; rs3117940; rs2833952; exm-rs4142041; rs10261983; rs7403021; rs1764109; rs1999874; rs1354156; rs10142804; rs4895598; rs329095; exm634421; rs1781740; rs17119479; rs6603867; rs16927986; exm2268830; rs2406067; rs906475; rs11141878; rs4454154; rs3745913; rs7142575; rs17026284; rs11580074; rs6700410; rs8040937; rs1577808; rs8056247; rs2651980; rs17103253; rs4805038; rs2503838; rs12094886; rs481145; rs10886222; rs2824153; exm-rs7217319; rs8022851; exm2268323; rs10756061; kgp874165; rs1876304; rs4730044; rs11653011; rs2477893; rs10518707; rs2296006; rs3825422; rs1607498; rs7976497; rs7513053; rs7787128; rs7411507; rs11155050; rs4953640; rs11256351; exm2270172; 및 exm2268119로 구성된 군에서 선택되는 단일염기 다형성의 소수 대립인자(minor allele)의 빈도가 높거나,rs12186488; rs560978; rs10444397; rs1370182; rs729129; rs2876142; rs4883194; rs419958; exm-rs9303277; rs9368649; rs2706859; rs10887273; rs7987260; rs1153451; rs12543745; rs1357616; rs11132829; rs7996510; rs7359943; rs9890911; rs7774359; rs7224129; rs10840701; exm217591; rs4631821; rs6468864; exm2270205; rs3990579; rs6703335; rs12488994; rs10894219; rs1475539; rs989023; rs1076710; rs2919471; rs1490051; rs7776974; rs7134553; rs2143934; rs7771293; rs10790969; exm-rs1999805; exm29843; rs4247116; rs10850508; rs12042467; rs6061245; rs3742039; rs10788679; rs4620259; rs2023405; rs924992; rs7950479; rs16827308; rs2884029; rs7893643; rs4850014; rs7093309; exm-rs830998; rs2652024; rs10492797; rs9676717; rs16853934; rs2838808; rs16961303; rs6845317; rs17834306; rs1967380; rs12938347; rs10130832; rs11140976; rs2728060; rs12708583; rs2760547; rs10500751; rs7589434; rs1816713; rs7582882; rs12444352; rs4880802; exm2259513; rs10845265; rs6650254; rs10900864; rs17063391; rs1884062; rs888444; rs763448; rs7805578; rs850254; rs4785193; rs2853651; rs12637875; exm68990; rs12709528; rs5015847; rs11149863; rs10859547; rs3812741; exm529509; rs7541950; rs12901901; rs8075604; rs7563451; rs1889170; rs12278256; rs4729671; rs7633394; rs205474; rs17064318; rs772305; rs6587673; rs11891861; rs3096279; rs10179086; rs1025246; rs6758936; rs2146971; rs2076339; rs6708202; rs11260542; rs10075707; rs516125; rs150207; rs4298454; rs17039519; rs10512197; rs885962; rs17051193; kgp11307318; rs12495599; rs1921561; rs7827405; rs9468829; rs2242448; rs2152310; rs4859540; rs9534442; rs16851176; rs2115619; rs36693; rs874697; rs2268689; rs871167; rs10407076; rs6495246; rs1026504; rs6589722; rs4954603; rs1925189; rs914978; rs10078324; rs17154601; rs535780; rs17391596; rs7211140; rs9999955; rs2025448; rs338415; exm-rs9912468; rs3744583; rs12326115; rs1442849; rs4918237; rs2041874; rs11844663; rs1827656; rs4843257; rs3109433; rs10206626; rs10866177; exm-rs12917698; rs4671327; rs11264352; rs2855510; rs1160575; rs11140989; rs4553283; rs7213078; rs1881584; rs4673364; rs1959919; rs17063374; rs1892356; rs1321368; rs2246053; rs7516050; rs464526; exm-rs8055236; rs11098326; rs4727001; rs10734897; rs425140; exm-rs8067378; rs1515656; rs7972655; rs6485247; rs2995765; rs11724270; rs1888363; rs7419051; rs6725395; rs7979863; rs11155607; rs10485734; rs842990; rs2071042; exm-rs703842; rs12564800; rs758994; rs9989875; rs10859780; rs9347511; rs4896501; rs731573; rs2695; rs200760; rs7797565; rs10884017; rs2830885; rs12135243; rs6715109; rs9379168; rs2769330; rs7797977; exm573467; rs2039076; rs11673295; exm-rs6445975; rs2484661; rs7972640; rs10878824; rs2079278; rs9397196; rs2242174; rs7850923; rs2961638; rs10791393; rs7240224; rs11075440; rs3821873; rs4758371; rs2718107; rs1741327; exm1104615; rs3923477; rs931258; rs9303016; rs11123636; exm2258282; kgp11032999; rs13176223; rs4144116; rs2128434; exm1545953; rs2453727; rs1860261; rs436806; rs17676607; rs7908544; exm2266655; rs10777331; rs7937695; rs949280; rs2101938; rs686262; rs7552304; rs2618148; rs1531807; rs6768580; rs776754; rs10128729; rs11788529; rs12372169; rs3013300; rs17056307; rs2240322; rs788040; rs6734462; rs1219538; rs12683296; rs1346028; rs9939521; rs2581566; rs1074390; exm2252025; rs252895; rs4446534; rs6947160; rs1825225; rs10008418; rs1805126; rs11677281; rs12647338; rs407050; rs1330742; exm-rs3094694; rs2898656; rs11700063; rs4939726; rs17443388; rs10756644; rs10984425; rs7312751; rs1421463; exm2265762; rs7701633; rs4852178; rs10737772; rs12548556; rs6553317; rs4741606; exm770959; rs6979207; rs4602829; rs10056747; rs7541494; exm2260947; rs12440161; rs1275680; rs4798157; rs12641446; rs9967427; rs11648981; rs2073242; rs6587905; rs1257193; rs7506794; rs1981905; rs6601105; exm2251246; rs1217744; exm2257389; rs2691583; rs4867032; rs944722; rs4262792; rs1629172; rs6681092; rs6731061; rs4752200; rs9574681; rs12497502; rs4745450; rs7309847; rs6973480; rs4547102; exm1415695; rs12048287; rs4574937; rs6512171; rs11710380; rs7420856; rs7126614; rs17011359; rs7095596; rs6445961; rs9817356; rs8100697; rs10026312; rs2412048; exm2269560; rs12671333; rs956090; rs4617129; rs13241587; rs1857994; rs12092254; exm1542; rs7214443; exm-rs10777332; exm508989; rs11655336; exm104672; rs1948147; rs1048380; rs2298155; 및 rs934819로 구성된 군에서 선택되는 단일염기 다형성의 소수 대립인자(minor allele)의 빈도가 낮은 경우 천식 발병 위험이 높은 것으로 예측하는 것을 특징으로 하는 정보제공방법
5 5
제2항에 있어서,상기 단일염기 다형성은 rs9994584; rs998666; rs998310; rs997868; rs9978352; rs997779; rs995773; rs9950726; rs9934908; rs9905908; rs9876922; rs9858118; rs9855702; rs9847111; rs9843194; rs9816536; rs9814567; rs9767548; rs968059; rs9674202; rs9647441; rs9597681; rs9593109; rs9576321; rs9563732; rs9519494; rs9513974; rs9506567; rs9488105; rs947732; rs946438; rs945246; rs9411446; rs940482; rs9397197; rs9397196; rs9394577; rs939219; rs935613; rs935549; rs934426; rs9311208; rs9304265; rs9302725; rs924992; rs918689; rs911448; rs897144; rs891137; rs889104; rs887802; rs879543; rs877886; rs855586; rs854651; rs832170; rs8114995; rs8100697; rs809192; rs8076629; rs8075604; rs8064923; rs8058898; rs8036994; rs8009944; rs7997607; rs7996510; rs7994343; rs7987260; rs7953873; rs792806; rs7910805; rs7897333; rs7895943; rs7894221; rs7856856; rs7828691; rs7827405; rs7827290; rs7805578; rs7783868; rs7776974; rs7771542; rs7771293; rs7761329; rs7732695; rs7714122; rs770369; rs7702491; rs7690336; rs7685634; rs7680331; rs766021; rs7655084; rs7645365; rs7640220; rs7627455; rs7619189; rs7602715; rs7600489; rs7598162; rs7547751; rs7541494; rs7530906; rs7522039; rs7508325; rs7487262; rs747004; rs7427492; rs7411507; rs7358830; rs7335730; rs7306764; rs7296403; rs7296166; rs7294819; rs729129; rs7260781; rs7253055; rs7252224; rs7242136; rs7216064; rs7214443; rs721385; rs7213078; rs7179528; rs7178867; rs7171150; rs7156893; rs7148759; rs7137194; rs713547; rs7135238; rs7134003; rs7114186; rs7113273; rs711145; rs710258; rs7091218; rs7048728; rs7046039; rs7044945; rs7027771; rs701855; rs7017149; rs7013866; rs7011741; rs7007741; rs6994627; rs6979207; rs6969015; rs696459; rs6938448; rs6935727; rs6928498; rs6921285; rs6920211; rs6918446; rs6892658; rs6880752; rs6873317; rs6865469; rs6857753; rs6854137; rs6841219; rs6830199; rs6822612; rs6821225; rs6779752; rs6765634; rs6748006; rs6740918; rs6737602; rs6736756; rs6734836; rs6733362; rs6725609; rs6722551; rs6720533; rs6710937; rs6702910; rs6655953; rs6650254; rs659406; rs6584940; rs6583698; rs6578821; rs6574495; rs6570845; rs6563127; rs6553317; rs654789; rs651922; rs6500842; rs6488271; rs6481643; rs6458548; rs645580; rs6452775; rs6449031; rs6434504; rs6433615; rs630973; rs626795; rs615746; rs6139831; rs6132153; rs6113922; rs608638; rs6085122; rs6077585; rs6067559; rs6064464; rs6059349; rs6056954; rs6040822; rs6027034; rs6025087; rs6022045; rs599287; rs598758; rs579687; rs5750824; rs5750031; rs5748955; rs567600; rs543831; rs528736; rs527430; rs516567; rs511567; rs511223; rs4954265; rs495062; rs4942587; rs4940617; rs4937339; rs4916960; rs4896501; rs4881260; rs4867981; rs4866437; rs4864099; rs4859540; rs4854150; rs4843257; rs4789580; rs4785193; rs4772723; rs4769248; rs4758051; rs4752200; rs4745856; rs4740922; rs4730954; rs4729671; rs4723496; rs4722372; rs4720196; rs4697273; rs4695959; rs4694519; rs4692196; rs4691567; rs4684017; rs4673364; rs4663369; rs4640621; rs4631821; rs4607068; rs4584758; rs4581141; rs4572929; rs454006; rs4532345; rs4520729; rs4517302; rs4503985; rs447270; rs441482; rs4388459; rs4378607; rs4359199; rs434097; rs4294679; rs4282227; rs4265402; rs4261436; rs4257585; rs425140; rs4233833; rs419958; rs41539; rs4147644; rs4142551; rs406292; rs404005; rs4029774; rs3990579; rs3945761; rs3940483; rs3935268; rs3923322; rs3920646; rs3906153; rs3904473; rs3859337; rs3851424; rs3849834; rs3848021; rs3846114; rs383623; rs3820445; rs3816933; rs3801721; rs3788976; rs3773008; rs3771892; rs3760188; rs3754443; rs3748060; rs358748; rs357967; rs349554; rs34385187; rs327457; rs3176767; rs31568; rs315499; rs313393; rs3117940; rs3109433; rs3088305; rs2968686; rs2964129; rs2963259; rs2961365; rs2939739; rs2924632; rs2913615; rs2912089; rs2897442; rs287624; rs2853651; rs28417430; rs2828098; rs28263; rs2824733; rs2815492; rs2815478; rs2789726; rs2788864; rs2762567; rs2748784; rs2741373; rs2728060; rs2706859; rs2704476; rs2683405; rs2644441; rs262152; rs2553670; rs2544630; rs252749; rs2513513; rs2495478; rs2495012; rs2479563; rs243039; rs2426817; rs2415461; rs2405826; rs2402526; rs2394287; rs2392415; rs2391535; rs238129; rs2367315; rs236448; rs2363696; rs2350700; rs2333825; rs2320467; rs2270399; rs2269596; rs2254300; rs2252403; rs2252321; rs2250759; rs2227562; rs2213840; rs2212969; rs2202815; rs2195294; rs219221; rs2190073; rs2160093; rs2158793; rs2145041; rs2120233; rs2100700; rs2098836; rs2094188; rs2075093; rs2074027; rs2069408; rs2057291; rs2049026; rs2039197; rs2031604; rs2029569; rs2028001; rs2023823; rs20195; rs1992373; rs1985317; rs1984843; rs1982959; rs1980661; rs1976; rs1957280; rs1956369; rs1946706; rs1927377; rs1925359; rs1922551; rs1912861; rs1900669; rs1896180; rs1891246; rs1890112; rs1887677; rs1884062; rs1878406; rs1853155; rs1847035; rs1827656; rs180438; rs1801260; rs178397; rs17801274; rs17793718; rs17770116; rs17736941; rs17652171; rs17626899; rs17612742; rs17540154; rs17496751; rs17456256; rs17450338; rs17423188; rs17420140; rs17391596; rs17226385; rs17170189; rs17158702; rs17125331; rs17115807; rs17114286; rs17094912; rs17067137; rs17051193; rs17039201; rs17032979; rs1702919; rs16999587; rs16959781; rs16947973; rs16936512; rs16933522; rs16933519; rs16906689; rs16898954; rs16887552; rs16866241; rs16854930; rs168282; rs1678618; rs1648136; rs1647292; rs1624391; rs1618566; rs1596306; rs1584262; rs1562612; rs1558473; rs1553474; rs1553092; rs1545344; rs1532579; rs1514032; rs1510158; rs1506508; rs1505552; rs1485197; rs1472180; rs1470104; rs1468515; rs1443797; rs1433110; rs1419305; rs1415808; rs1407584; rs1404372; rs1402517; rs1399403; rs1398944; rs1368464; rs1351656; rs1345887; rs13433257; rs13426616; rs13416893; rs13381320; rs1333015; rs13294519; rs13273087; rs13251949; rs13241427; rs13226109; rs1321847; rs13200960; rs1318297; rs1317722; rs13176223; rs13162213; rs13154347; rs13144861; rs13139198; rs13132206; rs13117654; rs13093006; rs13086529; rs13013816; rs13003233; rs12999094; rs12940887; rs12923754; rs12901901; rs12894598; rs12875434; rs1282275; rs12821011; rs12709528; rs12699156; rs12682632; rs12673437; rs12654778; rs1265236; rs12648621; rs12646841; rs12615167; rs12566028; rs12554627; rs12548503; rs1253105; rs12526741; rs12521931; rs12507758; rs1247122; rs12401878; rs12376965; rs12370099; rs12341814; rs12317051; rs12303266; rs12298894; rs12278256; rs12249943; rs12234378; rs12216384; rs12159290; rs12135243; rs12096164; rs12094886; rs12091032; rs12064537; rs1205726; rs12041851; rs1202592; rs12021818; rs12000024; rs11991397; rs11982066; rs11966818; rs11936879; rs11927332; rs11912647; rs11906354; rs11903904; rs11854068; rs11847459; rs11807917; rs11772032; rs11745164; rs11744028; rs11712964; rs11634684; rs1160575; rs11572727; rs1156909; rs1129174; rs11264359; rs11259210; rs11256351; rs11236827; rs11227871; rs11198243; rs11177441; rs11176442; rs11159326; rs11157365; rs11149863; rs1114707; rs11133; rs11127653; rs11123636; rs11119972; rs11109064; rs11108958; rs11099064; rs1109816; rs11097465; rs11086860; rs11082017; rs11078360; rs11056399; rs11054402; rs11051470; rs11018031; rs11002773; rs10998959; rs10993008; rs10951983; rs10938478; rs10928532; rs10924867; rs10894075; rs10893681; rs10886273; rs10870261; rs10867272; rs10863965; rs10859940; rs10859547; rs10859204; rs10854872; rs10848825; rs10839696; rs10822238; rs10812286; rs10797400; rs10795685; rs10787292; rs10787147; rs10774490; rs1076710; rs10758513; rs10756653; rs10745970; rs10519963; rs10517908; rs10513838; rs10507132; rs10503236; rs10500962; rs10500956; rs10498688; rs10497368; rs10485734; rs10481666; rs10461642; rs10444397; rs10407076; rs1039428; rs10281434; rs1027719; rs10218738; rs10196661; rs10196450; rs10165754; rs10131909; rs10131165; rs10130832; rs1012831; rs10125595; rs10124883; rs10121085; rs10092413; rs10091964; rs10078324; rs10056340; rs10049840; rs1002005; rs10009981; rs10001487; kgp6156665; kgp3323585; kgp11841852; exm991616; exm96593; exm96044; exm929913; exm888494; exm885867; exm86859; exm803307; exm779455; exm779446; exm779424; exm779421; exm761666; exm688755; exm597163; exm549800; exm477080; exm446348; exm41221; exm394034; exm385882; exm377263; exm332419; exm308004; exm305261; exm29843; exm290624; exm241897; exm233298; exm229606; exm2273473; exm2272734; exm2272277; exm2271460; exm2269019; exm2268830; exm2268320; exm2266840; exm2266222; exm2265935; exm2265883; exm2265839; exm2264957; exm2264151; exm2250083; exm1986597; exm1778040; exm169834; exm1622259; exm1545953; exm1493180; exm1425543; exm130185; exm1255254; exm120972; exm1104615; exm1006206; exm-rs7702187; exm-rs6916921; exm-rs476463; exm-rs4333130; exm-rs4282339; exm-rs40457; exm-rs385893; exm-rs3094121; exm-rs2901964; exm-rs2239187; exm-rs2082871; exm-rs2075650; exm-rs2025236; exm-rs1585471; exm-rs1522232; exm-rs1464510; exm-rs11669592; exm-rs10490775; 및 exm-rs10063647로 구성된 군에서 선택되고,상기 알레르기성 질환은 아토피성 피부염(atopic dermatitis, AD)인 것을 특징으로 하는 정보제공방법
6 6
제5항에 있어서,rs2479563; rs1596306; exm2250083; rs13416893; rs13200960; rs7011741; rs997779; rs7598162; rs7856856; rs2120233; rs313393; rs5750824; rs4517302; rs2100700; rs516567; rs10131909; rs7134003; rs7895943; rs7732695; rs10503236; rs696459; rs12041851; rs10938478; rs879543; rs9593109; rs17540154; rs3945761; rs7114186; rs4745856; rs1202592; rs7294819; rs2495478; rs766021; rs17115807; rs2031604; rs608638; rs6880752; rs7953873; rs6077585; rs934426; rs10951983; rs2098836; rs946438; rs434097; rs1956369; exm2269019; rs10924867; rs7640220; rs17420140; kgp3323585; rs2815492; rs4520729; exm2268830; rs599287; rs7137194; rs701855; rs4692196; rs2644441; rs12699156; rs441482; rs7600489; rs6938448; rs17094912; rs7619189; exm2272277; exm2272734; rs10893681; rs855586; rs1847035; rs17652171; rs1485197; rs9411446; rs262152; rs2039197; rs454006; rs6720533; rs911448; rs854651; rs13086529; rs1853155; rs4233833; rs12094886; rs947732; rs1002005; rs12234378; rs1647292; rs10196450; rs2964129; rs6139831; rs7411507; rs219221; rs17032979; rs9304265; rs10854872; rs721385; rs1472180; rs1282275; exm41221; rs2963259; rs10056340; rs4789580; rs287624; rs7627455; rs528736; rs4294679; exm2273473; rs357967; rs6574495; rs1321847; rs7179528; rs9563732; rs12554627; rs1985317; rs897144; rs11912647; rs7027771; rs7017149; rs2057291; rs2158793; rs13093006; rs4722372; rs11097465; rs11198243; rs2815478; rs168282; rs511223; rs4640621; rs17067137; rs1205726; rs178397; rs1468515; rs4147644; rs11936879; rs968059; rs7690336; rs1890112; rs7994343; rs6935727; rs358748; rs2190073; exm86859; rs6710937; rs495062; exm991616; rs9905908; rs13426616; rs567600; rs7828691; rs2250759; rs6488271; exm290624; rs11176442; rs2069408; rs10500962; rs3748060; rs12875434; rs2074027; rs2495012; rs17456256; rs6064464; rs41539; rs10839696; rs7135238; rs6056954; rs10092413; rs1433110; rs1404372; rs1351656; rs6433615; rs1333015; rs10519963; rs2704476; exm332419; rs2391535; rs2683405; rs3849834; rs6481643; rs10497368; rs1345887; rs6830199; exm-rs2082871; rs7508325; rs16906689; rs4954265; rs4532345; rs16854930; rs7487262; rs9506567; rs3117940; rs615746; rs6452775; rs11712964; rs12091032; exm-rs3094121; exm477080; rs7048728; rs10886273; rs1265236; rs9302725; rs243039; rs11119972; rs10498688; rs12940887; rs11982066; rs3801721; rs2075093; rs10507132; rs12548503; rs11109064; rs1545344; kgp6156665; exm446348; rs11903904; rs945246; exm233298; rs6584940; rs626795; rs4758051; rs6025087; rs2202815; rs6865469; rs10795685; rs3788976; rs11991397; rs1156909; rs10812286; rs10091964; rs4723496; rs877886; rs9513974; rs236448; rs1510158; rs7530906; rs1012831; rs238129; rs1129174; rs4916960; rs4864099; rs4772723; rs792806; exm1425543; rs6040822; rs31568; rs11018031; rs7306764; exm2266840; rs1039428; rs13251949; rs2028001; rs2227562; rs6765634; rs4694519; rs16947973; rs6841219; rs7714122; rs10125595; rs11906354; rs7761329; exm-rs476463; rs6059349; rs659406; rs4261436; rs11127653; exm305261; rs13381320; rs10758513; rs11159326; rs3848021; exm2266222; rs1253105; rs2350700; exm130185; rs7827290; rs1532579; rs16898954; rs1553092; rs9847111; rs9488105; rs6458548; rs2254300; rs2405826; rs16999587; rs12159290; rs16933522; rs3846114; rs6969015; rs11927332; rs6067559; exm-rs385893; exm-rs2901964; rs4867981; rs3935268; rs17423188; rs939219; rs10049840; rs16936512; rs2145041; rs1553474; rs4684017; rs3816933; exm761666; rs17170189; rs17039201; rs7013866; rs13154347; rs11133; rs17736941; rs935549; rs13241427; rs12673437; rs1407584; exm308004; rs7156893; rs9767548; exm-rs4282339; rs7296403; rs4572929; exm-rs7702187; rs3923322; rs12894598; rs1946706; rs1398944; rs28263; rs4942587; rs10124883; rs3771892; rs17125331; rs2269596; rs8036994; rs1982959; rs10500956; rs10928532; rs16959781; rs10863965; rs6583698; rs6928498; rs1419305; rs12654778; rs10218738; rs9576321; rs8114995; rs6449031; rs12401878; exm-rs1464510; rs12821011; rs406292; rs7655084; rs10196661; rs16933519; exm2264151; rs7252224; exm229606; rs6578821; exm-rs4333130; exm1986597; 및 rs3176767로 구성된 군에서 선택되는 단일염기 다형성의 소수 대립인자(minor allele)의 빈도가 높거나,rs13117654; exm779446; rs13139198; exm779455; rs7214443; rs2897442; exm779421; rs2402526; rs4843257; rs8076629; exm96044; rs6892658; rs2741373; rs9311208; rs17114286; rs11847459; rs34385187; rs1558473; rs2029569; rs6722551; rs13273087; rs11082017; rs918689; rs1878406; exm-rs40457; rs3851424; rs12682632; rs383623; rs1584262; exm779424; rs12615167; rs7645365; rs10281434; rs9816536; rs7910805; rs9519494; rs3940483; rs6702910; rs9843194; rs8009944; rs7897333; rs2333825; rs7148759; rs4631821; rs11054402; rs9647441; rs7805578; rs6854137; rs10485734; rs7044945; rs9394577; rs6500842; rs7091218; rs9855702; rs1470104; rs13013816; rs1925359; rs2553670; rs511567; rs7894221; rs17496751; rs2426817; rs20195; rs11123636; rs1506508; exm29843; rs1922551; rs2252321; rs1114707; rs7242136; rs17793718; rs2049026; rs9814567; rs2270399; rs1801260; rs1109816; exm2265935; rs12216384; exm549800; rs7997607; rs5748955; exm1778040; rs2762567; rs10859204; rs11966818; rs6650254; rs4785193; rs747004; rs1415808; exm2271460; rs1984843; rs2968686; rs8100697; rs13433257; rs7427492; exm1493180; rs11056399; rs10993008; rs17612742; rs12901901; exm-rs10063647; rs6822612; rs10444397; rs710258; rs6655953; rs9597681; rs10822238; rs10131165; rs2961365; rs997868; rs3904473; rs527430; rs10078324; rs315499; rs4769248; rs3920646; rs4282227; rs5750031; rs11157365; rs7046039; rs7113273; rs11854068; rs11108958; rs1368464; rs4581141; rs1912861; rs10870261; rs6022045; rs1317722; rs889104; rs10165754; rs3990579; rs2213840; rs4607068; rs6740918; rs1076710; rs6725609; rs4854150; rs11744028; rs1896180; rs6994627; rs2363696; rs425140; rs12303266; rs598758; rs654789; rs1992373; exm2265839; rs349554; rs711145; rs9978352; rs2788864; exm-rs1522232; rs2023823; rs8058898; rs7358830; rs12521931; rs1027719; rs7296166; rs11772032; rs832170; rs1648136; rs6873317; rs12298894; rs4503985; exm-rs1585471; rs7541494; exm241897; rs3754443; rs7685634; rs4673364; exm1006206; rs1980661; rs4584758; rs6132153; rs12341814; rs7771293; rs11259210; rs10009981; rs1884062; rs7702491; rs1887677; rs11634684; rs2748784; exm885867; rs10859547; rs12021818; rs11236827; rs13003233; rs13294519; rs6737602; exm-rs6916921; exm96593; rs4265402; rs4257585; rs13132206; rs1247122; rs1514032; rs7216064; rs4359199; rs1702919; rs2728060; rs2367315; rs7335730; rs9858118; rs4720196; rs998666; rs940482; rs1443797; rs2824733; rs9934908; rs7253055; exm1255254; rs12566028; rs11745164; rs12249943; rs12317051; rs4866437; rs10848825; rs6434504; rs10001487; rs1891246; rs11227871; rs2513513; exm597163; rs6734836; rs2544630; rs10867272; rs404005; rs11086860; exm1622259; rs327457; rs11002773; rs7171150; rs11256351; rs1678618; rs12507758; exm394034; rs2320467; rs9674202; rs1957280; rs6920211; rs2924632; rs4029774; rs10859940; rs2160093; rs9397196; rs11177441; rs2913615; rs12278256; rs7260781; rs630973; exm803307; rs11078360; rs12709528; rs28417430; rs10481666; rs10894075; exm120972; rs3773008; rs9950726; rs713547; rs1318297; rs13162213; exm2264957; rs12923754; rs6085122; rs6570845; rs4695959; rs2912089; rs809192; exm377263; rs17051193; rs12096164; exm1545953; exm-rs2025236; rs16866241; rs7776974; rs4752200; rs3820445; rs4388459; rs4740922; rs10407076; rs2853651; exm1104615; rs11572727; rs11099064; rs3109433; rs12648621; rs4940617; rs2252403; rs10774490; rs11807917; exm169834; rs252749; rs10998959; rs2789726; rs6748006; rs1402517; rs891137; rs10787292; rs8064923; rs4697273; rs2094188; rs4730954; rs12526741; rs1160575; rs17226385; rs12370099; rs12646841; rs935613; rs4896501; rs17450338; rs995773; rs7680331; rs924992; rs6736756; rs6921285; rs2392415; rs6113922; rs12000024; rs998310; exm-rs11669592; rs10461642; rs7783868; rs419958; rs447270; rs7213078; rs887802; rs11051470; rs7996510; rs2394287; rs13176223; rs3760188; rs4691567; rs4859540; rs8075604; rs7602715; rs12376965; exm-rs2239187; rs1624391; exm2268320; rs2828098; rs17158702; rs1618566; rs9397197; rs6918446; rs6733362; rs2195294; rs770369; rs1976; rs4378607; rs180438; rs6027034; rs13226109; rs7771542; rs17770116; rs6979207; rs3906153; rs579687; rs2939739; rs6553317; rs10797400; rs11149863; rs6563127; rs10121085; rs4937339; rs3088305; exm929913; rs17801274; rs12999094; rs9876922; rs1505552; rs1399403; rs16887552; rs2415461; rs543831; rs10130832; rs4663369; kgp11841852; rs17391596; exm2265883; rs10517908; rs11264359; rs7547751; rs7987260; rs6857753; rs729129; exm-rs2075650; rs6779752; rs6821225; rs13144861; rs2212969; rs4881260; rs7007741; rs1562612; exm-rs10490775; rs7178867; rs1900669; rs4729671; rs645580; rs7522039; rs12135243; rs10745970; rs3859337; rs651922; rs1827656; exm688755; rs17626899; rs1927377; rs9994584; exm385882; exm888494; rs7827405; rs10756653; rs4142551; rs10513838; rs10787147; rs12064537; 및 rs2706859로 구성된 군에서 선택되는 단일염기 다형성의 소수 대립인자(minor allele)의 빈도가 낮은 경우 아토피성 피부염 발병 위험이 높은 것으로 예측하는 것을 특징으로 하는 정보제공방법
7 7
제2항에 있어서,상기 단일염기 다형성은 rs9999955; rs9977556; rs9921866; rs9875174; rs9868938; rs9867036; rs9847462; rs9804729; rs9803860; rs975563; rs973237; rs969825; rs9672839; rs9662260; rs9590896; rs9550983; rs9531221; rs9508434; rs9506567; rs9468829; rs9459589; rs9422941; rs9400121; rs9397196; rs9367207; rs933956; rs914331; rs913913; rs911448; rs905809; rs8114269; rs8092433; rs8082686; rs807752; rs8060803; rs8045408; rs7996510; rs7987260; rs797536; rs7932225; rs7916009; rs7910586; rs7909432; rs7902; rs7867513; rs785260; rs7822183; rs7808471; rs7776980; rs7767825; rs7757300; rs7751661; rs7693606; rs7688384; rs766757; rs7646194; rs7639103; rs7627455; rs761901; rs7600784; rs7576952; rs7574100; rs7541201; rs7538519; rs7524543; rs7519860; rs7516050; rs7513053; rs7512315; rs7453910; rs742711; rs738443; rs7359943; rs7339152; rs7329551; rs727628; rs7240846; rs723898; rs7214443; rs7213078; rs7178668; rs7148452; rs7115663; rs7114186; rs7091625; rs709113; rs7049205; rs7036689; rs7025913; rs7010142; rs7007741; rs6979207; rs6973480; rs6943730; rs6942436; rs6926104; rs6914238; rs6910246; rs6890531; rs6854035; rs6821225; rs6815091; rs6800399; rs6798375; rs6742567; rs6736756; rs668714; rs6670304; rs6656933; rs6587673; rs6571754; rs6570845; rs6555593; rs6546923; rs6500824; rs6485247; rs6478451; rs6463343; rs637151; rs626795; rs6113922; rs6109532; rs6089553; rs599287; rs582714; rs5750824; rs5750031; rs5015975; rs5002678; rs4998984; rs4983262; rs4942859; rs4942587; rs4928089; rs4927133; rs4910146; rs4896709; rs4883194; rs4867981; rs4859540; rs4793900; rs4758371; rs4757702; rs4734509; rs4729671; rs4727001; rs4703374; rs4670876; rs4649274; rs4646644; rs4637174; rs4631821; rs4631014; rs4620259; rs4581141; rs4560089; rs4553616; rs4520412; rs4517302; rs4478425; rs4415740; rs4269418; rs4261436; rs4236315; rs4150161; rs40638; rs3896235; rs3851366; rs3806405; rs3785185; rs3773008; rs3771892; rs3742039; rs358734; rs34892353; rs346830; rs329652; rs3118386; rs309570; rs2982384; rs2930736; rs2912089; rs2900856; rs28859095; rs2884128; rs2855510; rs2853651; rs2838808; rs2833788; rs28260; rs2824332; rs2790450; rs2790381; rs2728060; rs2709580; rs2670170; rs2651980; rs2644441; rs2614166; rs2572363; rs2513513; rs2506145; rs2483678; rs2472459; rs2464266; rs2453665; rs2439411; rs2406067; rs2392243; rs2388257; rs2350700; rs2347267; rs2325401; rs2300850; rs2294065; rs2286219; rs225517; rs2251065; rs2249339; rs2232669; rs2231390; rs2217628; rs2216746; rs2206671; rs219221; rs2190073; rs2187025; rs2154346; rs2120233; rs2115374; rs2109971; rs2108609; rs2074289; rs2074027; rs2073019; rs2071018; rs2059283; rs2057916; rs2028103; rs2028001; rs2000560; rs1890554; rs1887181; rs1863601; rs1863401; rs1861436; rs1821803; rs181048; rs180438; rs17841095; rs17746899; rs17736941; rs17732046; rs1767182; rs176004; rs17578049; rs17564391; rs17540154; rs17443388; rs17234274; rs17173801; rs17118244; rs17118093; rs17109804; rs17094912; rs17039201; rs17018037; rs16961303; rs16895902; rs16876177; rs16849710; rs16826060; rs1665164; rs166403; rs1656216; rs1627193; rs1561150; rs1539282; rs1538590; rs1536041; rs1506508; rs1484555; rs1479827; rs1469099; rs1439107; rs1402578; rs1402517; rs1394130; rs1380643; rs1379736; rs13424754; rs13384147; rs13382004; rs13356323; rs13331665; rs13278499; rs13103435; rs13044386; rs13030183; rs13028762; rs12999094; rs12945571; rs12920359; rs1288312; rs12638422; rs12610606; rs12555424; rs12511039; rs12497256; rs12492432; rs12488922; rs12486625; rs12476717; rs12421329; rs12192603; rs12125971; rs12112697; rs12035144; rs11971013; rs11944163; rs11927332; rs11884157; rs11866218; rs11860538; rs11779793; rs11765661; rs11747629; rs11673295; rs11665792; rs11659972; rs11643145; rs11572727; rs1151444; rs11256351; rs11183625; rs11177441; rs11157691; rs11136055; rs11108958; rs1110798; rs11102707; rs11058480; rs1102309; rs10976463; rs10962386; rs10961908; rs10954673; rs10938478; rs10919242; rs10910843; rs10887936; rs10874098; rs10848825; rs10785943; rs1078579; rs10774424; rs10759009; rs10751938; rs10749283; rs10738451; rs1065399; rs10507132; rs10495963; rs1035441; rs10268511; rs10265677; rs10264866; rs10231416; rs10224650; rs10217074; rs10196011; rs10141127; rs10130832; rs10117909; rs10039326; rs10029104; rs1002005; rs10012347; kgp6605617; kgp6156665; exm865411; exm865261; exm830447; exm830151; exm783763; exm770959; exm751990; exm738753; exm68990; exm646305; exm641834; exm547609; exm529574; exm529509; exm425753; exm425196; exm332419; exm244559; exm241897; exm232229; exm2271749; exm2271460; exm2269993; exm2268964; exm2268830; exm2268210; exm2267767; exm2267689; exm2265896; exm2261971; exm2261447; exm2261240; exm2254257; exm2251246; exm2250654; exm2159517; exm1705530; exm1584701; exm148888; exm1410803; exm1311709; exm1141883; exm1059867; exm-rs9501626; exm-rs9303277; exm-rs7216389; exm-rs6852535; exm-rs4729759; exm-rs2516683; exm-rs2290400; 및 exm-rs11023787로 구성된 군에서 선택되고,상기 알레르기성 질환은 천식-아토피성 피부염 동반 질환인 것을 특징으로 하는 정보제공방법
8 8
제7항에 있어서,rs3785185; exm1141883; exm2250654; exm529574; rs5750824; rs7909432; rs10738451; rs4236315; rs2231390; rs10495963; rs10962386; rs7767825; rs2187025; rs2028001; rs17540154; exm830447; rs1394130; rs8060803; rs9422941; rs17173801; rs2059283; rs7513053; rs4560089; exm1584701; rs2206671; rs7538519; exm1059867; rs7902; rs6109532; rs9400121; rs4942587; rs5015975; rs10029104; rs2071018; exm2159517; exm1705530; rs1861436; rs11927332; exm244559; rs17094912; rs11659972; rs9531221; rs12488922; rs2074289; rs2651980; exm783763; rs7519860; rs4983262; exm-rs9501626; rs10224650; rs2115374; rs761901; rs7757300; rs7627455; rs4517302; rs10507132; rs6854035; rs9672839; rs2824332; rs7693606; rs10954673; kgp6156665; rs9804729; rs2644441; rs7049205; rs6910246; rs2350700; rs13103435; rs2120233; exm2268830; rs2670170; rs12555424; rs2190073; rs16849710; rs4631014; rs668714; rs17564391; rs181048; rs12476717; rs7114186; rs2057916; rs9662260; rs4261436; rs11866218; rs1110798; rs2347267; rs11183625; rs4734509; rs2614166; rs6914238; rs11256351; rs3771892; rs17841095; rs4269418; rs12192603; rs10012347; rs742711; rs975563; rs4928089; rs10774424; rs329652; exm1410803; exm2268964; rs2709580; exm2261971; exm738753; rs7240846; rs4867981; rs9590896; rs7639103; rs7910586; rs11136055; rs6656933; rs6463343; rs727628; exm865261; rs2833788; rs738443; rs599287; rs6546923; rs9506567; exm148888; rs4896709; rs2506145; rs7646194; rs3118386; rs11971013; rs10910843; rs10785943; rs1002005; rs723898; rs28859095; rs4910146; rs626795; rs13278499; rs2483678; kgp6605617; rs7576952; exm2271749; rs1538590; rs8092433; rs1402578; rs1151444; rs9508434; rs219221; rs12112697; exm2254257; rs2930736; rs6798375; rs1887181; rs11665792; rs2108609; rs12511039; rs8082686; rs7339152; rs7600784; rs12125971; rs7524543; rs807752; exm2268210; rs2073019; rs16895902; rs11747629; rs2325401; rs17039201; rs2216746; rs4415740; exm2261447; rs911448; rs9847462; rs17018037; rs2790381; rs1665164; rs2406067; rs637151; rs1863601; rs10141127; rs2900856; rs6943730; rs933956; rs10938478; rs7329551; rs1484555; rs9875174; rs13384147; rs1767182; rs13331665; rs7010142; rs1627193; rs7808471; exm830151; rs2472459; rs1380643; rs7574100; rs4757702; rs6742567; rs1561150; rs2074027; rs6089553; rs17736941; rs766757; exm332419; rs4670876; rs2439411; exm-rs2516683; rs2294065; rs8114269; rs785260; rs11102707; rs1656216; exm865411; exm232229; 및 rs1102309로 구성된 군에서 선택되는 단일염기 다형성의 소수 대립인자(minor allele)의 빈도가 높거나,exm2251246; exm-rs7216389; rs7214443; rs10919242; rs10751938; rs914331; rs17732046; rs4927133; exm-rs4729759; rs1821803; rs7115663; rs7359943; rs12920359; rs11860538; rs10231416; rs2232669; rs9921866; exm425196; rs7036689; rs1479827; rs11157691; rs16826060; rs6570845; rs10887936; rs225517; rs10848825; rs11572727; exm-rs6852535; rs17109804; rs2838808; rs2855510; rs11884157; rs3896235; rs7822183; rs12945571; exm2267767; rs7148452; rs2392243; rs17234274; rs11643145; rs17443388; rs16961303; rs11673295; rs2249339; rs4150161; rs7453910; rs7091625; rs4942859; rs7178668; exm770959; rs4998984; rs10264866; rs9977556; rs9550983; rs7007741; rs12497256; rs3806405; rs17118093; rs13382004; exm646305; rs1379736; rs5002678; rs6890531; rs7776980; rs13424754; exm751990; rs166403; rs2853651; rs4649274; rs10976463; rs13028762; rs2513513; rs7867513; exm425753; rs2912089; rs11779793; rs1065399; exm1311709; rs5750031; rs7996510; rs7025913; rs7516050; rs7932225; rs10196011; rs34892353; rs6800399; rs4478425; rs9397196; rs8045408; rs12610606; exm-rs2290400; rs969825; rs17746899; rs28260; rs10117909; rs9868938; rs7751661; rs1439107; rs13030183; rs1506508; rs4703374; rs2300850; rs4520412; rs10874098; exm547609; rs4581141; exm2271460; exm641834; rs3742039; rs176004; rs6926104; rs2464266; rs13356323; rs709113; rs2217628; rs10217074; rs797536; rs17578049; rs2982384; rs6973480; rs12421329; rs12486625; rs1402517; rs1288312; rs973237; rs6587673; rs17118244; rs4883194; rs9867036; rs1078579; exm2261240; rs1863401; rs6979207; rs4631821; rs582714; rs346830; rs2388257; rs4727001; rs2109971; exm-rs9303277; rs10268511; rs12035144; rs2028103; rs4793900; rs6670304; rs2790450; rs9367207; rs3773008; rs4637174; rs1536041; exm2267689; rs1035441; rs2453665; rs905809; rs7512315; rs10961908; exm2265896; rs4620259; rs10130832; rs16876177; rs6500824; rs6478451; rs2154346; rs4646644; rs7541201; rs11765661; rs1469099; rs4553616; rs9999955; rs10039326; rs1890554; rs6815091; rs9468829; rs7688384; rs9803860; rs4758371; rs6555593; exm241897; rs2572363; rs2000560; rs3851366; rs10759009; rs6485247; rs10265677; rs10749283; rs358734; rs6942436; rs4859540; rs13044386; rs180438; rs6821225; rs12638422; exm-rs11023787; rs11058480; rs2286219; rs12999094; rs4729671; rs7987260; rs2728060; rs2884128; rs11108958; exm529509; rs6571754; rs7213078; rs2251065; rs913913; rs7916009; rs6736756; rs309570; rs9459589; rs11177441; rs12492432; rs6113922; exm2269993; rs40638; rs1539282; rs11944163; 및 exm68990로 구성된 군에서 선택되는 단일염기 다형성의 소수 대립인자(minor allele)의 빈도가 낮은 경우 천식-아토피성 피부염 동반 질환 발병 위험이 높은 것으로 예측하는 것을 특징으로 하는 정보제공방법
9 9
제1항에 있어서, 상기 가족력 정보는 2촌 이내 친족의 알레르기성 천식, 비염, 피부염, 또는 음식물 알레르기의 발병 정보를 포함하는 것을 특징으로 하는 정보제공방법
10 10
제1항에 있어서, 상기 (c) 단계는 하기 수식 1로 계산하는 것을 특징으로 하는 정보제공방법:수식 1 여기서, 는 질병 여부, 는 질환 발병 확률 또는 기대값, 는 logit 함수, 는 성별 및 가족력 위험 점수, 는 성별 및 가족력 위험 점수 각각에 대응되는 회귀 계수, 는 각 SNP의 소수 대립인자(minor allele)의 빈도, 는 각 SNP에 대응되는 회귀 계수임
11 11
제10항에 있어서, 상기 회귀 계수는 하기 수식 2로 계산하는 것을 특징으로 하는 정보제공방법:수식 2 여기서, 는 각각의 회귀 계수의 추정치, 는 의 값을 대입한 로그-가능도 함수의 값, 는 의 값을 대입한 벌점 함수의 값임
12 12
제11항에 있어서, 상기 벌점 함수는 LASSO(Least Absolute Shrinkage and Selection Operator) 모델 또는 능선 회귀(ridge regression) 모델을 이용하여 계산하는 것을 특징으로 하는 정보제공방법:여기서, 상기 LASSO 모델은 하기 수식 3으로 계산하며,수식 3 수식 3에서, 는 벌점화 매개변수(penalization parameter), 는 SNP별 회귀 계수의 절대값의 총합인 L1 노름(norm)이고,상기 능선 회귀 모델은 하기 수식 4로 계산하며,수식 4 수식 4에서, 는 벌점화 매개변수(penalization parameter), 는 SNP별 회귀 계수의 제곱합의 양의 제곱근인 L2 노름(norm)이며,수식 2와 수식 3 또는 수식 4를 통해 추정한 각각의 회귀 계수 추정치를 수식 1에 대입한 후 계산한 선형 예측자(예측 변수의 값과 각각에 대한 회귀 계수의 곱의 총합)의 값이 1
13 13
제1항에 있어서, 상기 생물학적 시료는 혈액, 모발, 타액, 소변, 정액, 질 세포, 구강세포, 태반세포 또는 태아세포를 포함하는 양수 및 이의 혼합물로 구성된 군에서 선택되는 시료인 것을 특징으로 하는 정보제공방법
14 14
제1항에 있어서, 상기 핵산은 게놈 DNA, cfDNA(cell free DNA), RNA 또는 micro RNA인 것을 특징으로 하는 정보제공방법
15 15
제1항에 있어서, 상기 알레르기성 질환은 나이는 4세 내지 20세인 소아의 알레르기성 질환인 것을 특징으로 하는 정보제공방법
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순번 연구부처 주관기관 연구사업 연구과제
1 교육부 연세대학교 이공학개인기초연구지원사업 알레르기 질환 후성유전학적 타겟 발굴 및 기능 규명