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단일 염기 다형성을 이용한 동아시아인의 HLA-A, HLA-B, HLA-C, HLA-DPB1 또는 HLA-DQB1 유전자형 분석 방법(Method for Imputing Classical Alleles of HLA-A, HLA-B, HLA-C, HLA-DPB1 or HLA-DQB1 Using Single Nucleotide Polymorphisms in East Asian Population)

  • 기술번호 : KST2016007785
  • 담당센터 : 서울서부기술혁신센터
  • 전화번호 : 02-6124-6930
상담신청 PDF 받기
요약, Int. CL, CPC, 출원번호/일자, 출원인, 등록번호/일자, 공개번호/일자, 공고번호/일자, 국제출원번호/일자, 국제공개번호/일자, 우선권정보, 법적상태, 심사진행상태, 심판사항, 구분, 원출원번호/일자, 관련 출원번호, 기술이전 희망, 심사청구여부/일자, 심사청구항수의 정보를 제공하는 이전대상기술 뷰 페이지 상세정보 > 서지정보 표입니다.
요약 본 발명은 동아시아인의 HLA-A, HLA-B, HLA-C, HLA-DPB1 또는 HLA-DQB1 유전형을 정확도 높게 예측할 수 있는 단일염기다형성 조합을 이용한 유전형 분석 방법에 관한 것이다. 본 발명의 조성물을 사용함으로써 높은 정확도로 간편하게 동아시아인의 HLA-A, HLA-B, HLA-C, HLA-DPB1 또는 HLA-DQB1 유전형을 예측할 수 있다.
Int. CL C12Q 1/68 (2006.01) G06F 19/10 (2011.01) G01N 33/48 (2006.01)
CPC C12Q 1/6813(2013.01) C12Q 1/6813(2013.01)
출원번호/일자 1020140118945 (2014.09.05)
출원인 한양대학교 산학협력단
등록번호/일자
공개번호/일자 10-2016-0029948 (2016.03.16) 문서열기
공고번호/일자
국제출원번호/일자
국제공개번호/일자
우선권정보
법적상태 공개
심사진행상태 수리
심판사항
구분 신규
원출원번호/일자
관련 출원번호
심사청구여부/일자 Y (2014.09.05)
심사청구항수 9

출원인

번호, 이름, 국적, 주소의 정보를 제공하는 이전대상기술 뷰 페이지 상세정보 > 인명정보 - 출원인 표입니다.
번호 이름 국적 주소
1 한양대학교 산학협력단 대한민국 서울특별시 성동구

발명자

번호, 이름, 국적, 주소의 정보를 제공하는 이전대상기술 뷰 페이지 상세정보 > 인명정보 - 발명자 표입니다.
번호 이름 국적 주소
1 김광우 대한민국 경상남도 양산시 평산북로 ,
2 이혜순 대한민국 서울특별시 광진구
3 배상철 대한민국 서울특별시 송파구
4 방소영 대한민국 서울특별시 송파구

대리인

번호, 이름, 국적, 주소의 정보를 제공하는 이전대상기술 뷰 페이지 상세정보 > 인명정보 - 대리인 표입니다.
번호 이름 국적 주소
1 김주형 대한민국 서울특별시 강남구 논현로***, *층(논현동, 구산빌딩)(해움특허법인)
2 오경진 대한민국 서울특별시 강남구 논현로***, *층(논현동, 구산빌딩)(해움특허법인)
3 김웅 대한민국 서울특별시 강남구 논현로***, *층(논현동, 구산빌딩)(해움특허법인)

최종권리자

번호, 이름, 국적, 주소의 정보를 제공하는 이전대상기술 뷰 페이지 상세정보 > 인명정보 - 최종권리자 표입니다.
번호 이름 국적 주소
최종권리자 정보가 없습니다
번호, 서류명, 접수/발송일자, 처리상태, 접수/발송일자의 정보를 제공하는 이전대상기술 뷰 페이지 상세정보 > 행정처리 표입니다.
번호 서류명 접수/발송일자 처리상태 접수/발송번호
1 [특허출원]특허출원서
[Patent Application] Patent Application		 2014.09.05 수리 (Accepted) 1-1-2014-0853603-71
2 출원인정보변경(경정)신고서
Notification of change of applicant's information		 2015.02.16 수리 (Accepted) 4-1-2015-5022074-70
3 선행기술조사의뢰서
Request for Prior Art Search		 2015.03.10 수리 (Accepted) 9-1-9999-9999999-89
4 선행기술조사보고서
Report of Prior Art Search		 2015.05.11 수리 (Accepted) 9-1-2015-0033382-52
5 의견제출통지서
Notification of reason for refusal		 2016.05.26 발송처리완료 (Completion of Transmission) 9-5-2016-0385208-65
6 [지정기간연장]기간연장(단축, 경과구제)신청서
[Designated Period Extension] Application of Period Extension(Reduction, Progress relief)		 2016.07.26 수리 (Accepted) 1-1-2016-0727402-03
7 [지정기간연장]기간연장(단축, 경과구제)신청서
[Designated Period Extension] Application of Period Extension(Reduction, Progress relief)		 2016.08.26 수리 (Accepted) 1-1-2016-0835122-79
8 [지정기간연장]기간연장(단축, 경과구제)신청서
[Designated Period Extension] Application of Period Extension(Reduction, Progress relief)		 2016.09.19 수리 (Accepted) 1-1-2016-0905506-73
9 [대리인선임]대리인(대표자)에 관한 신고서
[Appointment of Agent] Report on Agent (Representative)		 2016.09.22 수리 (Accepted) 1-1-2016-0919240-06
10 거절결정서
Decision to Refuse a Patent		 2017.01.25 발송처리완료 (Completion of Transmission) 9-5-2017-0064234-92
11 출원인정보변경(경정)신고서
Notification of change of applicant's information		 2019.08.05 수리 (Accepted) 4-1-2019-5155816-75
12 출원인정보변경(경정)신고서
Notification of change of applicant's information		 2019.08.06 수리 (Accepted) 4-1-2019-5156285-09
번호, 청구항의 정보를 제공하는 이전대상기술 뷰 페이지 상세정보 > 청구항 표입니다.
번호 청구항
1 1
분석 대상(subject)으로부터 유래한 생물학적 시료로부터 분리한 핵산 시료로부터, 하기 SNP 목록 1의 단일 염기 다형성 조합을 분석하여 상기 단일 염기 다형성들의 유전자형들을 결정하는 단계를 포함하는 동아시아인의 HLA(human leukocyte antigen)-A, HLA-B, HLA-C, HLA-DPB1 또는 HLA-DQB1 유전자형 결정을 위한 데이터 수집 방법:SNP 목록 1rs7739830, rs1880271, rs11751616, rs6908645, rs522024, rs807213, rs807211, rs807203, rs1179007, rs707903, rs1183694, rs806972, rs2298090, rs2298091, rs806966, rs806978, rs806792, rs438534, rs3857549, rs6921148, rs13195509, rs4713002, rs13194984, rs7768682, rs9295700, rs7751878, rs7741445, rs6932003, rs6904071, rs6913660, rs6921711, rs17737028, rs13194053, rs12210982, rs9468019, rs9461345, rs7746199, rs9468031, rs11965377, rs2893912, rs9468058, rs11967073, rs9969094, rs11962403, rs2393997, rs6908615, rs4713119, rs7742752, rs12192568, rs6915101, rs9468227, rs9295749, rs2021835, rs11962868, rs9468236, rs11970638, rs7748520, rs7742529, rs10456357, rs6910968, rs6922530, rs7769416, rs7741570, rs6913038, rs10484404, rs3734572, rs7747772, rs9468293, rs6908414, rs6932313, rs1150671, rs6929559, rs1233667, rs1233698, rs1736892, rs3757183, rs6918043, rs2799076, rs11966237, rs11965542, rs1150725, rs7759855, rs6922161, rs6902583, rs6456812, rs9295769, rs6908459, rs7759845, rs6918631, rs6929449, rs9468346, rs2859379, rs3757181, rs719370, rs2859367, rs2531808, rs2531810, rs2531816, rs6927023, rs722788, rs423118, rs11757235, rs426922, rs413488, rs422089, rs454746, rs449074, rs411538, rs420436, rs7738979, rs11969304, rs911178, rs4711176, rs7742658, rs6925972, rs1319076, rs6456832, rs9468413, rs6456834, rs11754985, rs11963531, rs209181, rs9501112, rs176461, rs7775657, rs209139, rs12386522, rs6934470, rs9468459, rs9295784, rs9468461, rs9468464, rs3129795, rs9468469, rs9468474, rs3129106, rs9468487, rs3129157, rs3130801, rs11962388, rs11964645, rs6899390, rs9468508, rs3117433, rs9348827, rs7761746, rs9257792, rs9257803, rs9257805, rs11969272, rs16894919, rs2073148, rs2746149, rs16894948, rs1362076, rs7771335, rs2107189, rs17415601, rs2066951, rs17184114, rs9393967, rs7767894, rs2294748, rs9461533, rs9391895, rs6930217, rs6935418, rs10484548, rs362541, rs3025657, rs6902738, rs7763501, rs16895058, rs6915177, rs2076486, rs64036, rs2272991, rs362532, rs459970, rs6912437, rs3025650, rs3117073, rs17508548, rs3095273, rs362518, rs2267633, rs2076483, rs2076482, rs29267, rs29264, rs29230, rs29246, rs29243, rs29273, rs3131854, rs9257928, rs16895214, rs439812, rs29269, rs29272, rs29231, rs29235, rs9468571, rs3135050, rs2857783, rs2256266, rs2857784, rs6905408, rs3130253, rs2535250, rs2535248, rs2857771, rs2071652, rs1318631, rs2071653, rs2273192, rs2747419, rs9257940, rs378596, rs9257985, rs3117301, rs2747453, rs2747454, rs2747457, rs2747458, rs2747460, rs2747466, rs3129039, rs3129029, rs3129066, rs9258102, rs6911622, rs2107203, rs3129055, rs9258122, rs3116798, rs2394660, rs3131863, rs11962017, rs1476573, rs1476572, rs1610594, rs1611364, rs2735063, rs1632962, rs2517911, rs2517910, rs9258170, rs1362126, rs2076183, rs9258186, rs1736926, rs2235383, rs1736922, rs1628578, rs2523404, rs2735059, rs2272874, rs3736694, rs2743925, rs2523402, rs2523399, rs2735052, rs2844833, rs2523395, rs2394159, rs2394160, rs9258205, rs9258206, rs1736915, rs1736913, rs9258207, rs9258208, rs9258209, rs2735051, rs9258211, rs2844831, rs9258213, rs932338, rs1633096, rs9258218, rs2743951, rs2517938, rs909732, rs4713240, rs2523386, rs9258225, rs2072894, rs2523385, rs34260811, rs1633085, rs733841, rs1610621, rs909728, rs909725, rs4713244, rs9391630, rs9258260, rs1633068, rs1737079, rs1633057, rs1633056, rs1610628, rs1633048, rs1737069, rs7759474, rs1611285, rs1626392, rs1625636, rs1737060, rs1633041, rs2735048, rs2735046, rs1737043, rs1737041, rs11753872, rs9258302, rs9258303, rs1615962, rs2844836, rs1633021, rs1002046, rs2743941, rs7758742, rs1610644, rs1633011, rs11758087, rs2523414, rs11752553, rs11751333, rs1611185, rs2017525, rs3891160, rs1610711, rs1736982, rs1736981, rs1611192, rs1632988, rs1632987, rs17178826, rs9258447, rs11757182, rs2523409, rs1736971, rs1736969, rs1610699, rs3926748, rs11753629, rs11753654, rs1077432, rs2735028, rs2743933, rs2743931, rs2394177, rs1611149, rs1736936, rs3115630, rs915669, rs1233330, rs11753296, rs16896052, rs2394180, rs2735014, rs9258525, rs2523779, rs2743937, rs2735003, rs9258537, rs2523777, rs2523776, rs1611133, rs2523774, rs2523769, rs2844827, rs16896081, rs2734994, rs2523767, rs2517879, rs9258557, rs2394185, rs2394186, rs9380146, rs3115628, rs2247504, rs2508050, rs3115627, rs2523756, rs9258631, rs2517862, rs3115626, rs2517855, rs2517854, rs3132726, rs6919513, rs1611684, rs9258738, rs17185692, rs2523822, rs9295822, rs3094170, rs1611717, rs9258766, rs9258771, rs765649, rs1611737, rs1611738, rs2524035, rs3094165, rs2734974, rs2734973, rs2517826, rs9258866, rs3132718, rs9258883, rs3094654, rs3132714, rs2523809, rs2523808, rs2517904, rs2524024, rs2860580, rs3823342, rs6921314, rs2735097, rs1655900, rs2523949, rs9260497, rs404046, rs429511, rs2523942, rs2517700, rs9260679, rs441808, rs9260722, rs9260734, rs3903160, rs6457109, rs2844806, rs3893259, rs4713270, rs3869062, rs3893464, rs9260759, rs9260761, rs17186496, rs2517673, rs4713275, rs1061535, rs6916422, rs2523969, rs2523961, rs2523960, rs2256902, rs2523946, rs3823355, rs2844804, rs3823358, rs2232238, rs2232239, rs2523943, rs6904029, rs2735076, rs2394250, rs2893999, rs3823374, rs2571375, rs3823384, rs9260860, rs2108691, rs9260915, rs423808, rs2571430, rs2246638, rs2394255, rs401618, rs2735067, rs11757750, rs17186937, rs11755961, rs3901554, rs5025708, rs12665186, rs9260930, rs12662611, rs9260967, rs9260984, rs6457121, rs6910898, rs9260997, rs9260998, rs9261040, rs6941318, rs6904120, rs9261079, rs9261081, rs9261091, rs11760176, rs9261093, rs11965524, rs2286405, rs2286404, rs9261105, rs356968, rs6940082, rs2240619, rs3765604, rs9261115, rs9261129, rs11753431, rs3734836, rs9261130, rs9261138, rs16896044, rs6457126, rs356954, rs9357092, rs9261145, rs6926792, rs6931776, rs165256, rs4711206, rs9261151, rs3891157, rs3129012, rs3891156, rs6919617, rs1150743, rs9261171, rs9261174, rs4448133, rs9261189, rs16896923, rs9261193, rs3121593, rs166327, rs3869067, rs3869068, rs9261203, rs259938, rs3910312, rs9261216, rs259939, rs259940, rs9261224, rs259942, rs3132128, rs6457138, rs7771476, rs6457140, rs28570682, rs7761314, rs9261257, rs9261258, rs3869070, rs9261261, rs9261263, rs6911724, rs259919, rs6917477, rs10484549, rs9261265, rs3757328, rs3757329, rs3757333, rs9295829, rs1150742, rs7770092, rs7770505, rs10745, rs9261269, rs9261270, rs1150740, rs9261277, rs3188482, rs3807030, rs3807031, rs9261285, rs2074482, rs9261288, rs1245371, rs2301753, rs2301751, rs9393989, rs2074480, rs2074479, rs9261301, rs9261302, rs3807033, rs3132682, rs3807035, rs1150735, rs2394734, rs4711209, rs9261316, rs7382061, rs2057728, rs9261361, rs9261371, rs17187805, rs9261387, rs6923832, rs7765810, rs9261394, rs1264702, rs916570, rs1264701, rs1264698, rs7763159, rs1108052, rs1110446, rs2240070, rs1116222, rs1116221, rs11964542, rs2844796, rs2248289, rs3132680, rs2523992, rs2523988, rs2523987, rs2517597, rs2523986, rs2523981, rs2523979, rs9261434, rs17455565, rs10947056, rs2523995, rs3132676, rs9468693, rs3094134, rs3757334, rs12212092, rs9261536, rs2857449, rs17188127, rs2074475, rs1063280, rs13212414, rs9261538, rs2517623, rs9261547, rs4476873, rs10947058, rs11967808, rs11961294, rs1345229, rs9295837, rs3094138, rs3094137, rs10456378, rs2508028, rs9261588, rs928824, rs28780093, rs1264622, rs8973, rs3094631, rs7758503, rs1264608, rs1264581, rs12663184, rs7767653, rs3129838, rs6931763, rs6905389, rs3132649, rs3094061, rs3130375, rs3130379, rs3094622, rs3094621, rs2057726, rs3129808, rs3129809, rs3130361, rs11759238, rs7772240, rs3129817, rs3129820, rs3132631, rs3132630, rs3129822, rs3132625, rs1245218, rs7744914, rs28780099, rs3094032, rs3130126, rs3094050, rs17475879, rs3130116, rs9261761, rs9261821, rs9261846, rs1573294, rs9261895, rs9261919, rs9261922, rs9261923, rs9261926, rs9261947, rs9501447, rs1079541, rs9295863, rs9295871, rs9295873, rs4947284, rs9295886, rs17411480, rs35407515, rs34101875, rs9501336, rs11966619, rs35792611, rs2524172, rs2516670, rs28780106, rs3757335, rs12192673, rs4713337, rs3132611, rs4148248, rs1264429, rs9348841, rs2517565, rs17195551, rs1079687, rs3094104, rs3132608, rs2269708, rs1076829, rs9262138, rs3130000, rs1076828, rs3094098, rs2285322, rs3094097, rs17189246, rs2285321, rs6937357, rs9468805, rs9262141, rs2269707, rs2239887, rs2394392, rs3129996, rs2249059, rs3094092, rs2269703, rs2239886, rs28994872, rs2269702, rs28986466, rs6929626, rs17189329, rs28986465, rs2075015, rs6924270, rs3132587, rs9461624, rs4713354, rs3132584, rs25527, rs8233, rs9500864, rs3095329, rs35580157, rs3094127, rs12179975, rs9501029, rs1064627, rs3909184, rs9969042, rs9968884, rs9380182, rs12111310, rs10947088, rs10947089, rs2301277, rs12210092, rs6926530, rs11757629, rs17189427, rs3131064, rs1264377, rs3129987, rs3094123, rs3094111, rs1264352, rs9262216, rs3130785, rs3130648, rs11757306, rs9262222, rs3095345, rs11759095, rs9262256, rs7746003, rs9262280, rs3131034, rs6457281, rs3132572, rs3130779, rs3130780, rs3218822, rs7766094, rs4678, rs3131787, rs3095151, rs7764239, rs2844649, rs6933400, rs6933909, rs4711248, rs2844648, rs2844701, rs2844700, rs9391637, rs2517451, rs9368647, rs2247178, rs3094086, rs11970154, rs9368648, rs2429557, rs9295937, rs4711250, rs2844697, rs2530715, rs3095089, rs3132579, rs3131931, rs2517425, rs1634714, rs3873342, rs1634718, rs12528082, rs9262539, rs6903912, rs12198448, rs7768644, rs4711253, rs2517549, rs9262560, rs10947129, rs12528584, rs7756294, rs9295947, rs2394427, rs17190134, rs16898614, rs9262632, rs2517512, rs3906263, rs2523887, rs9380215, rs9263509, rs2894179, rs2517403, rs6919169, rs9263600, rs2844635, rs9391709, rs1265062, rs2233985, rs2233984, rs2233976, rs2233974, rs2270190, rs4495304, rs2233964, rs2233956, rs3823402, rs17190526, rs6917517, rs9295952, rs3130981, rs3132553, rs3132552, rs3132550, rs3130989, rs3132546, rs3095317, rs2239520, rs3095314, rs4410768, rs9295953, rs3778630, rs3778638, rs10947137, rs9263719, rs3130560, rs3734861, rs4959053, rs3130564, rs28732100, rs1265100, rs2233954, rs2233950, rs9263726, rs1265093, rs2233945, rs1966, rs9263733, rs2073718, rs9263739, rs11967883, rs130072, rs1265076, rs3132538, rs746647, rs9263749, rs1265114, rs1265112, rs130067, rs2517985, rs1265110, rs130077, rs130076, rs9263781, rs720465, rs9263785, rs6905862, rs6929434, rs2073724, rs9263794, rs1044870, rs17190776, rs9263796, rs3757349, rs9263800, rs12215963, rs885952, rs1108746, rs1265159, rs2269713, rs887468, rs3132517, rs3094188, rs1265156, rs9468877, rs4713438, rs9263823, rs9263846, rs9405015, rs1265178, rs28362332, rs28362343, rs3094609, rs6903896, rs10807081, rs9263870, rs6921948, rs4446605, rs3094606, rs2894181, rs9263911, rs3132506, rs9263916, rs3132505, rs35718543, rs3130952, rs3132503, rs9263948, rs9468898, rs28360990, rs3132501, rs9263979, rs12662501, rs9263993, rs3130521, rs28397289, rs6908994, rs3130473, rs3130528, rs7745906, rs2394892, rs3130685, rs2394895, rs28397299, rs3132499, rs6901869, rs3130695, rs4332019, rs9357117, rs2394950, rs2245822, rs2853961, rs3130542, rs9264532, rs9394047, rs34131062, rs9264602, rs9366775, rs2074488, rs9357121, rs2249742, rs7759127, rs5010528, rs6923313, rs2844613, rs3130696, rs2524074, rs9264731, rs2524073, rs9468913, rs2524068, rs9391714, rs6906846, rs17198616, rs9468914, rs2844603, rs9461684, rs2853935, rs2853933, rs2853930, rs2524048, rs2524044, rs9468924, rs2524043, rs3900938, rs2524040, rs9468925, rs2256583, rs2524163, rs2524162, rs2524160, rs9357122, rs2524156, rs3873380, rs9348863, rs3873381, rs2524132, rs2853925, rs2247056, rs3905495, rs2524115, rs17192463, rs13191519, rs2853922, rs2524089, rs9380238, rs9380240, rs2524066, rs9366778, rs3873385, rs3915971, rs9468935, rs7750269, rs9264851, rs9264869, rs9264870, rs9368675, rs9368677, rs9264904, rs9264916, rs7760988, rs364415, rs3873386, rs9500887, rs28380796, rs2844586, rs2523619, rs4394275, rs2523618, rs9391846, rs2596503, rs1058026, rs2596487, rs2523573, rs2596548, rs2596549, rs2523557, rs2523554, rs2523544, rs9266395, rs2523537, rs9266409, rs2844567, rs2253908, rs9266433, rs4358666, rs2844556, rs2254556, rs6933050, rs13202464, rs4959069, rs9501587, rs3094600, rs9266669, rs4143334, rs9266722, rs3016014, rs2442749, rs9266772, rs9266773, rs9266774, rs2523477, rs2523476, rs2523464, rs2523454, rs2844523, rs2844519, rs2263313, rs2857281, rs12174396, rs6910087, rs3828875, rs2256028, rs2848713, rs10223568, rs4418214, rs9501109, rs2524279, rs4346874, rs9501595, rs2524277, rs9469003, rs6938674, rs2524276, rs9267084, rs28575156, rs2844510, rs9765960, rs12206131, rs16899646, rs3128982, rs2596460, rs2596458, rs2395028, rs2596480, rs2523684, rs6930572, rs2255001, rs2255221, rs11752262, rs2395030, rs11757571, rs3094604, rs3094013, rs2516518, rs4713466, rs2395031, rs9267137, rs7758090, rs2844505, rs6940467, rs3131643, rs3828893, rs3749945, rs3749946, rs3099844, rs2905722, rs2905747, rs3094011, rs9267280, rs2904783, rs3130922, rs2395043, rs3134899, rs3131638, rs3131633, rs9267445, rs3094001, rs3131630, rs3130636, rs3093993, rs9469021, rs3095227, rs3093992, rs3093988, rs2516482, rs3093983, rs3093981, rs3093980, rs3115537, rs3219190, rs3093978, rs3130056, rs3093948, rs3131628, rs3093976, rs2734583, rs3130058, rs1129640, rs2516393, rs2523511, rs2523508, rs7738430, rs2239528, rs2523504, rs3219183, rs35969216, rs2255798, rs13192469, rs9469024, rs2857709, rs2857708, rs3093542, rs4248157, rs1800629, rs3093671, rs3093672, rs3093561, rs9267503, rs13211368, rs28732144, rs34816476, rs11575839, rs11755226, rs2509217, rs17200810, rs2857700, rs3132451, rs28732150, rs2736182, rs2736177, rs3130070, rs2280801, rs17200837, rs1046080, rs3130623, rs17207225, rs2736161, rs3130626, rs2736157, rs2272593, rs11538263, rs11538264, rs9267522, rs10885, rs9267525, rs3130628, rs7770976, rs35843778, rs2844463, rs10484558, rs3130050, rs3117583, rs805264, rs2273612, rs707921, rs28732157, rs707974, rs805259, rs928814, rs3130618, rs805258, rs9267529, rs3117578, rs805268, rs805267, rs11758242, rs805272, rs3115667, rs805269, rs9267533, rs9267534, rs9267536, rs10573, rs1475865, rs805283, rs1266071, rs9267545, rs34406901, rs805295, rs3793125, rs9469040, rs9469041, rs9469042, rs3749952, rs4713479, rs453098, rs3101018, rs28381339, rs28381346, rs707915, rs3117572, rs1150793, rs9296001, rs11754464, rs9461718, rs28399987, rs707936, rs707934, rs9461721, rs9461725, rs34585796, rs2273613, rs11751198, rs9296002, rs17201171, rs34636308, rs2227955, rs2227956, rs481825, rs16867582, rs34378923, rs13217108, rs35987121, rs9368699, rs9368700, rs17207629, rs11968400, rs9267577, rs9501157, rs13191375, rs9267649, rs13118, rs35092817, rs4947332, rs11966200, rs13192107, rs9267659, rs36097221, rs589428, rs486416, rs35875104, rs9267661, rs9469069, rs28732165, rs28435656, rs9267673, rs644045, rs511294, rs498240, rs9267677, rs9332705, rs11752672, rs2257331, rs9332735, rs635348, rs12614, rs9501161, rs9267785, rs34555781, rs9296003, rs492899, rs2280773, rs13217120, rs34241101, rs2075702, rs2854432, rs2746394, rs9391732, rs11757034, rs34214527, rs10046127, rs2077580, rs12198173, rs3749963, rs11751545, rs34878747, rs11756755, rs13199524, rs1269854, rs4713503, rs12153855, rs13196724, rs28732175, rs204892, rs4713504, rs11753510, rs13211318, rs388629, rs204999, rs28732178, rs3134608, rs34129552, rs3096697, rs3130347, rs34280838, rs3130284, rs2071290, rs3134947, rs3134945, rs3130349, rs12663103, rs9267820, rs2114437, rs3134942, rs3132935, rs6907458, rs17604492, rs3132956, rs2269418, rs3213468, rs8192591, rs430916, rs2071282, rs8192584, rs8192565, rs483574, rs482759, rs511027, rs28895018, rs28366174, rs6906662, rs9268199, rs6910071, rs498422, rs3132958, rs3132959, rs28732193, rs9469099, rs3117133, rs910049, rs12662503, rs2395148, rs3129907, rs2894249, rs2143462, rs3129931, rs3129937, rs3129939, rs3129941, rs2076535, rs2073045, rs9391858, rs3129945, rs9268425, rs9268428, rs2894252, rs2894253, rs8180664, rs9268454, rs9268456, rs28732201, rs6930777, rs9268461, rs9268474, rs28366191, rs2076528, rs2076527, rs3763305, rs2076525, rs2076524, rs3793127, rs3763309, rs3763310, rs3763312, rs3763315, rs3763316, rs9380293, rs9268516, rs9405098, rs3129963, rs2395163, rs2395165, rs2395166, rs9268557, rs6457580, rs3135344, rs9501626, rs11759143, rs3129860, rs7356880, rs2027856, rs3129868, rs6911777, rs3129883, rs3129886, rs3129887, rs2239805, rs11544315, rs2239802, rs2395182, rs3763326, rs28895103, rs28895187, rs7763262, rs28732227, rs9268831, rs9268926, rs7748472, rs3830135, rs9270665, rs28605404, rs2858870, rs602457, rs9270986, rs9271055, rs9271100, rs660895, rs9271170, rs35759989, rs4530903, rs642093, rs13204672, rs9271348, rs3135005, rs9271366, rs17533090, rs2097431, rs3129763, rs9271588, rs35399661, rs9271775, rs9272219, rs3104369, rs2187668, rs9273012, rs17843604, rs9273327, rs9273349, rs6906021, rs1063355, rs9273448, rs2854275, rs7775228, rs9275224, rs2858324, rs9275245, rs5000634, rs17427431, rs6457617, rs6457622, rs2647003, rs9357152, rs9275312, rs2856725, rs9275330, rs9275333, rs35998847, rs3135006, rs17427599, rs2858308, rs2856717, rs2858305, rs2856705, rs13192471, rs1794275, rs4947344, rs9275572, rs3129727, rs7765379, rs2858332, rs9275595, rs7454108, rs3957146, rs9275596, rs3998159, rs3957148, rs3873444, rs3892710, rs3997854, rs6915986, rs6936707, rs9275659, rs9275686, rs9275698, rs763026, rs2859099, rs9276310, rs7773068, rs7773694, rs7755597, rs9276399, rs17500468, rs2213565, rs9276435, rs28986337, rs28986338, rs28986359, rs28986364, rs10484564, rs28986373, rs13204139, rs28986396, rs7758736, rs9276722, rs11967235, rs2071471, rs3763355, rs3763354, rs9784876, rs16870907, rs13209654, rs10484565, rs9380326, rs4148872, rs4148871, rs241428, rs13215, rs17213812, rs16871027, rs2071538, rs4148878, rs28724900, rs35571244, rs10214510, rs9469311, rs35599935, rs6934645, rs12206377, rs1480380, rs6906517, rs11757089, rs2894311, rs9276969, rs3128933, rs3129304, rs3129303, rs3129302, rs3130603, rs9276992, rs3130604, rs3130607, rs423639, rs17214311, rs3130609, rs397576, rs6933319, rs34493748, rs763469, rs7738815, rs376877, rs2395309, rs3077, rs2301226, rs1054025, rs1042190, rs10214910, rs2301220, rs9277341, rs6914849, rs1431399, rs1431400, rs1431401, rs2051548, rs9380340, rs2071349, rs2071351, rs2071353, rs3135021, rs1042151, rs2856826, rs9378177, rs9277378, rs9277396, rs9277464, rs9277469, rs3097675, rs9277471, rs9277533, rs9277555, rs3117229, rs3117228, rs9277557, rs9277565, rs3130188, rs3091282, rs3117226, rs3117225, rs3097652, rs2068204, rs3128972, rs2179920, rs10484569, rs2179919, rs2281390, rs2281389, rs3128917, rs2281388, rs7763822, rs3117222, rs3128918, rs3130190, rs3130191, rs3117221, rs3130198, rs3117213, rs2395319, rs3117239, rs2064479, rs2064478, rs2064476, rs3117234, rs3117231, rs3130215, rs3117230, rs3128930, rs6457713, rs9380342, rs9380343, rs6937034, rs6937061, rs9348906, rs9277629, rs1810472, rs2395349, rs3117039, rs3117038, rs3117035, rs1883414, rs9277682, rs4713607, rs9277723, rs3117021, rs6913896, rs3129275, rs3117016, rs3117008, rs3117004, rs3116998, rs3130235, rs3130237, rs6901221, rs9277768, rs2294472, rs2395352, rs7756467, rs3129264, rs7750000, rs9366816, rs13437000, rs4713610, rs926421, rs3129249, rs9296086, rs7754200, rs3129234, rs3129231, rs3129228, rs3129223, rs3130151, rs2395365, rs3129214, rs721394, rs756441, rs756440, rs9277912, rs3129207, rs3129206, rs9277920, rs9368757, rs9380351, rs2235499, rs734181, rs2235498, rs986522, rs2855441, rs9368758, rs2855440, rs2855437, rs2855430, rs16868943, rs2269346, rs9469378, rs9277935, rs2076310, rs110662, rs439205, rs383711, rs421446, rs107822, rs213210, rs213208, rs1567464, rs213213, rs9277937, rs28892580, rs386084, rs17215210 ,rs12664430, rs6923740, rs761583, rs7752625, rs1755044, rs2772385, rs2772372, rs2772374, rs68191, rs169737, rs2296340, rs11753634 및 rs11758326
2 2
제 1 항에 있어서, 단계 (a)는 마이크로어레이(microarray)에 의한 혼성화 방법, 대립유전자 특이적 프로브 혼성화 방법(allele-specific probe hybridization), 대립 유전자 특이적 증폭 방법(allelespecific amplification), 서열분석법(sequencing), 5' 뉴클레아제 분해법(5' nuclease digestion), 분자 비콘 어세이법(molecular beacon assay), 올리고뉴클레오티드 결합 어세이법(oligonucleotide ligation assay), 크기 분석법(size analysis) 및 단일 가닥 배좌 다형성법(single-stranded conformation polymorphism)으로 이루어지는 군으로부터 선택되는 방법에 의해 수행되는 것을 특징으로 하는 방법
3 3
제 1 항에 있어서, 상기 생물학적 시료는 혈액, 조직, 세포, 혈청, 혈장, 타액, 객담 및 소변으로 이루어진 군으로부터 선택되는 어느 하나인 것을 특징으로 하는 방법
4 4
다음 단계를 포함하는 동아시아인의 HLA-A, HLA-B, HLA-C, HLA-DPB1 또는 HLA-DQB1 유전자형 분석 방법: (a) 청구항 제 1 항의 방법에 의해 분석 대상으로부터 HLA-A, HLA-B, HLA-C, HLA-DPB1 또는 HLA-DQB1 유전자형 결정을 위한 데이터를 수집하는 단계; 및(b) 단계 (a)로부터 얻은 단일 염기 다형성 조합의 유전자형들을, 상기 단일 염기 다형성 조합의 유전자형들과 HLA-A, HLA-B, HLA-C, HLA-DPB1 또는 HLA-DQB1의 유전자형의 연관성에 대한 사전 정보(predetermined information)를 제공하는 레퍼런스(reference)와 비교하여, 상기 분석 대상의 HLA-A, HLA-B, HLA-C, HLA-DPB1 또는 HLA-DQB1의 유전자형을 결정하는 단계
5 5
제 4 항에 있어서, 상기 HLA-A, HLA-B, HLA-C, HLA-DPB1 또는 HLA-DQB1의 유전자형은 4자리(digit) 대립유전자 해상도로 결정하는 것을 특징으로 하는 방법
6 6
제 4 항에 있어서, 상기 SNP 목록 1의 단일 염기 다형성들은 HLA-A, HLA-B, HLA-C, HLA-DPB1 또는 HLA-DQB1 유전형과 연관불균등(linkage disequilibrium) 지수(r2)가 0
7 7
SNP 목록 1의 단일 염기 다형성 조합, 또는 상기 조합의 각각의 단일 염기 다형성에 상보적인 서열을 갖는 올리고뉴클레오타이드를 포함하는 동아시아인의 HLA-A, HLA-B, HLA-C, HLA-DPB1 또는 HLA-DQB1 유전자형 분석용 키트
8 8
다음 단계를 포함하는 동아시아인의 HLA-A, HLA-B, HLA-C, HLA-DPB1 또는 HLA-DQB1 유전자형을 결정하는 방법을 컴퓨터 상에서 실행하기 위한 컴퓨터 프로그램:(a) 분석 대상(subject)으로부터 유래한 생물학적 시료로부터 분리한 핵산 시료로부터 얻은 SNP 목록 1의 단일 염기 다형성 조합의 유전자형 정보를 수신하는 단계; 및(b) 단계(a)로부터 얻은 단일 염기 다형성 조합의 유전자형 정보를, 상기 단일 염기 다형성 조합의 유전자형들과 HLA-A, HLA-B, HLA-C, HLA-DPB1 또는 HLA-DQB1의 유전자형의 연관성에 대한 사전 정보(predetermined information)를 제공하는 레퍼런스(reference) 데이터베이스와 비교하여, 상기 분석 대상의 HLA-A, HLA-B, HLA-C, HLA-DPB1 또는 HLA-DQB1의 유전자형을 결정하는 단계
9 9
제 8 항의 컴퓨터 프로그램을 포함하며, 상기 프로그램을 컴퓨터 상에서 실행하기 위하여 컴퓨터로 읽을 수 있는 기록매체
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